Evidence map›Paper›PMID 29378942›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility.

Abigail E Russi, Mark E Ebel, Yuchen Yang, Melissa A Brown

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 114 citations in OpenAlex.

  1. Targeting IL-33 in Precision Neuroimmunology: Cellular Mechanisms and Therapeutic Strategies for CNS Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Review
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  16. CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis.International journal of molecular sciences · 2024
    Review
  17. Review
  18. Type 2 immunity in the brain and brain borders.Cellular & molecular immunology · 2023
    Review
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Abigail E RussiDepartment of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Mark E EbelDepartment of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Yuchen YangDepartment of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Melissa A BrownDepartment of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 m-brown12@northwestern.edu.
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
FACSAria SORP Cell SorterS10OD011996 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOOLSBY, CHARLES L. · 2012 to 2012
$482k
Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL MiceR21NS081598 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BROWN, MELISSA A · 2012 to 2013
$418k
C-kit Signaling Pathways Regulate EAE Susceptibility in Male SJL MiceF31NS084691 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHORT, ABIGAIL ELIZABETH · 2013 to 2015
$143k
NCI NIH HHS P30 CA060553NIH HHS S10 OD011996NINDS NIH HHS F31 NS084691NINDS NIH HHS R21 NS081598
6 · The paper itself

Abstract

The cellular and molecular basis of sex-dimorphic autoimmune diseases, such as the CNS demyelinating disease multiple sclerosis (MS), remains unclear. Our studies in the SJL mouse model of MS, experimental autoimmune encephalomyelitis (EAE), reveal that sex-determined differences in

Indexed as

Sex CharacteristicsAnimalsCytokinesEncephalomyelitis, Autoimmune, ExperimentalFemaleInterleukin-33MaleMast CellsMiceMice, Inbred C57BLTestosteroneTh17 CellsCytokinesIl33 protein, mouseInterleukin-33TestosteroneIL-33ILC2mast cellssex-dimorphic EAEtestosterone

Identifiers

PMID29378942
PMCPMC5816140
OpenAlexW2790129187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.