ArticleProceedings of the National Academy of Sciences of the United States of America2018
Wireless optoelectronic photometers for monitoring neuronal dynamics in the deep brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 208 citations in OpenAlex.
- Local control of Cre-regulated genetic modeling in vivo using wireless implantable optoelectronics.Science advances · 2026Article
- Battery-free, fully wireless neurostimulation via radiative RF power transfer in freely behaving mice.Microsystems & nanoengineering · 2026Article
- A compact, wireless fluorimeter system for continuous, real-time monitoring of tissue perfusion via in vivo fluorescence signals.Science advances · 2026Article
- Miniscope Zero: a fully wireless, single-cell-resolution miniature microscope for imaging neural dynamics in freely behaving animals.bioRxiv : the preprint server for biology · 2026Article
- Multiwavelength Implantable Oximeter for Wireless Monitoring of Tissue Oxygenation in the Presence of Blood Volume Changes.Advanced healthcare materials · 2026Article
- X-optogenetic inhibition of VTA GABA neurons for wireless deep-brain stimulation and suppression of scratching behavior in freely moving mice.Materials today. Bio · 2026Article
- In vivo multimodal neurochemical interfaces for real-time decoding of brain circuit.Nature reviews. Neuroscience · 2026Review
- An Active, Multimodal Neural Interface for Real-Time Monitoring of Cortical Electrical, Thermal, and Optical Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fully Implanted Miniature Radio Controller Boosts Cyborg Insect Mobility in Challenging Terrains.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Flexible Dual-Modal Sensors Based on Single-Crystalline Silicon Membranes for Continuous Monitoring of Photoplethysmography and Skin Temperature.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Analysis and management of thermal loads generated in vivo by miniaturized optoelectronic implantable devices.Device · 2025Article
- A closed loop fully automated wireless vagus nerve stimulation system.Scientific reports · 2025Article
- A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals.Advanced healthcare materials · 2025Article
- Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025Article
- Chronic, Battery-Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Optogenetic activation of mechanical nociceptions to enhance implant osseointegration.Nature communications · 2025Article
- A soft multimodal optoelectronic array interface for multiparametric mapping of heart function in vivo.Science advances · 2025Article
- Identification of a stress-responsive subregion of the basolateral amygdala in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Mapping multi-regional functional connectivity of astrocyte-neuronal networks during behaviors.Neurophotonics · 2024Article
- Implantable photonic nano-modulators open perspectives for advanced optical interfaces with deep brain areas.Neurophotonics · 2024Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 3 countries.
Funding
Abstract
Capabilities for recording neural activity in behaving mammals have greatly expanded our understanding of brain function. Some of the most sophisticated approaches use light delivered by an implanted fiber-optic cable to optically excite genetically encoded calcium indicators and to record the resulting changes in fluorescence. Physical constraints induced by the cables and the bulk, size, and weight of the associated fixtures complicate studies on natural behaviors, including social interactions and movements in environments that include obstacles, housings, and other complex features. Here, we introduce a wireless, injectable fluorescence photometer that integrates a miniaturized light source and a photodetector on a flexible, needle-shaped polymer support, suitable for injection into the deep brain at sites of interest. The ultrathin geometry and compliant mechanics of these probes allow minimally invasive implantation and stable chronic operation. In vivo studies in freely moving animals demonstrate that this technology allows high-fidelity recording of calcium fluorescence in the deep brain, with measurement characteristics that match or exceed those associated with fiber photometry systems. The resulting capabilities in optical recordings of neuronal dynamics in untethered, freely moving animals have potential for widespread applications in neuroscience research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.