Evidence map›Paper›PMID 29378902›Full record

Observational studySexually transmitted infections2018

Asymptomatic lymphogranuloma venereum among Nigerian men who have sex with men.

Trevor A Crowell, Justin Hardick, Kara Lombardi, Zahra Parker, Afoke Kokogho, Senate Amusu, Sunday Odeyemi, Andrew Ivo, Stefan D Baral, Rebecca G Nowak and 5 more

Abstract readObservational Study
In one paragraph

Observational study in Sexually transmitted infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Trevor A CrowellU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID 0000-0001-5947-265X
Justin HardickJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kara LombardiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Zahra ParkerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Afoke KokoghoWalter Reed Program-Nigeria, Abuja, Nigeria.
Senate AmusuWalter Reed Program-Nigeria, Abuja, Nigeria.
Sunday OdeyemiWalter Reed Program-Nigeria, Abuja, Nigeria.
Andrew IvoWalter Reed Program-Nigeria, Abuja, Nigeria.
Stefan D BaralJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Rebecca G NowakInstitute of Human Virology, University of Maryland, Baltimore, Maryland, USA.
Sylvia AdebajoPopulation Council Nigeria, Abuja, Nigeria.
Manhattan E CharuratInstitute of Human Virology, University of Maryland, Baltimore, Maryland, USA.
Julie AkeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Charlotte A GaydosJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
TRUST/RV368 Study Group
Henry M. Jackson Foundation · USJohns Hopkins University · USUniversity of Maryland, Baltimore · USMedical Laboratory Science Council of Nigeria · NGWalter Reed Army Institute of Research · US

Funding

LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Matthew Hamill · 2007 to 2026
$34.6M
UM-IHV AITRP in NigeriaD43TW001041 · FIC · UNIVERSITY OF MARYLAND BALTIMORE · PI CHARURAT, MANHATTAN E · 1998 to 2015
$9.2M
Building TRUSTR01AI120913 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHARURAT, MANHATTAN E · 2015 to 2019
$3.3M
TRUSTR01MH099001 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CHARURAT, MANHATTAN E · 2012 to 2014
$2.9M
FIC NIH HHS D43 TW001041NIAID NIH HHS L30 AI120129NIAID NIH HHS R01 AI120913NIAID NIH HHS UM1 AI068613NIBIB NIH HHS U54 EB007958NIMH NIH HHS R01 MH099001
6 · The paper itself

Abstract

objectivesRecent outbreaks of anorectal lymphogranuloma venereum (LGV) among men who have sex with men (MSM) have been characterised by proctocolitis requiring extended antibiotic treatment compared with infections caused by other serovars of

methodsMSM were recruited for this observational cohort in Lagos, Nigeria, using respondent-driven sampling and screened for HIV and bacterial STIs every three months for up to 18 months. Nucleic acid amplification tests for CT were performed on rectal swab specimens. Prevalent and incident cases of anorectal CT underwent additional testing to identify LGV using novel real-time PCR assays specific for the L-serovars of CT.

resultsFrom April 2014 to July 2016, 420 MSM underwent testing for rectal STIs, of whom 66 (15.7%) had prevalent anorectal CT. Among those without prevalent disease, 68 developed incident infections during 208 person-years of follow-up. Of 134 prevalent and incident cases of anorectal CT, 7 (5.2%) were identified as LGV. None of the seven participants with LGV reported any symptoms. Two of the participants with LGV were simultaneously coinfected with rectal gonorrhoea. HIV coinfection was common among participants with both LGV (n=5, 71%) and non-LGV (n=98, 77%) serovars of CT (P=0.66).

conclusionsAnorectal LGV was uncommon but present among Nigerian MSM in this study. Consistent screening for L-serovars of CT, or presumptive treatment for LGV in cases with a high suspicion for this diagnosis, could potentially improve patient outcomes and decrease transmission.

Indexed as

Homosexuality, MaleAdolescentAdultAsymptomatic InfectionsChlamydia trachomatisCohort StudiesCoinfectionGonorrheaHIV InfectionsHumansLymphogranuloma VenereumMaleMass ScreeningNigeriaPrevalenceReal-Time Polymerase Chain ReactionAfricachlamydia trachomatisHIVlymphogranuloma venereummen who have sex with mensexually transmitted infection

Identifiers

PMID29378902
PMCPMC6064673
OpenAlexW2786300424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.