ArticleThe Journal of biological chemistry2018
Single-cell nanobiopsy reveals compartmentalization of mRNAs within neuronal cells.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Robot aided optical tweezers and microneedle assisted minimally invasive single cell mitochondria biopsy system.Medical & biological engineering & computing · 2026Article
- Neuronal subtype-specific ribosomal protein mRNA expression.RNA (New York, N.Y.) · 2026Article
- Applications of Nanopipettes in Scanning Ion Conductance Microscopy for High-Spatial-Resolution Topographic Imaging and Sensing in Single Cells.ACS measurement science au · 2026Review
- Delivery of Biomolecules into Individual Cells and Subcellular Compartments by Localized Electroporation via Nanopipette.ACS nanoscience Au · 2025Article
- Spatial and Temporal Single-Cell Profiling of RNA Compartmentalization in Neurons with Nanotweezers.ACS nano · 2025Article
- Mechanistic insights into the basis of widespread RNA localization.Nature cell biology · 2024Review
- Single-cell nanobiopsy enables multigenerational longitudinal transcriptomics of cancer cells.Science advances · 2024Article
- Recent advances in single-cell subcellular sampling.Chemical communications (Cambridge, England) · 2023Review
- The New Era of High-Throughput Nanoelectrochemistry.Analytical chemistry · 2023Review
- Subcellular RNA-seq for the Analysis of the Dendritic and Somatic Transcriptomes of Single Neurons.Bio-protocol · 2022Article
- Scanning Ion Conductance Microscopy.Chemical reviews · 2021Review
- Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons.eLife · 2021Article
- Nanoneedle-Based Materials for Intracellular Studies.Advances in experimental medicine and biology · 2021Article
- Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2021Review
- Axon microdissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons.RNA (New York, N.Y.) · 2020Article
- Active particles as mobile microelectrodes for selective bacteria electroporation and transport.Science advances · 2020Article
- Insights Into Translatomics in the Nervous System.Frontiers in genetics · 2020Review
- The Most Recent Advances in the Application of Nano-Structures/Nano-Materials for Single-Cell Sampling.Frontiers in chemistry · 2020Review
- Nanoscale tweezers for single-cell biopsies.Nature nanotechnology · 2019Article
- Accelerating a paradigm shift: The Common Fund Single Cell Analysis Program.Science advances · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
In highly polarized cells such as neurons, compartmentalization of mRNA and of local protein synthesis enables remarkably fast, precise, and local responses to external stimuli. These responses are highly important for neuron growth cone guidance, synapse formation, and regeneration following injury. Because an altered spatial distribution of mRNA can result in mental retardation or neurodegenerative diseases, subcellular transcriptome analysis of neurons could be a useful tool for studying these conditions, but current techniques, such as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.