Evidence map›Paper›PMID 29378832›Full record

ArticleMolecular and cellular biology2018

Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release.

Qiong L Zhou, Ye Song, Chun-Hong Huang, Jun-Yuan Huang, Zhenwei Gong, Zhangping Liao, Andria G Sharma, Lily Greene, Justin Z Deng, Michael C Rigor and 4 more

Abstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiong L Zhou *Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA qzhou@bu.edu zyjiang@bu.edu.
Ye Song *Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Chun-Hong HuangDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Jun-Yuan HuangDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Zhenwei GongIntegrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA.
Zhangping LiaoDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Andria G SharmaDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Lily GreeneDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Justin Z DengDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Michael C RigorDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Xiangyang XieIntegrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA.
Songtao QiDepartment of Neurosurgery, Nanfang Hospital & Southern Medical University, Guangzhou, Guangdong, China.
Julio E AyalaIntegrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA.
Zhen Y JiangDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA qzhou@bu.edu zyjiang@bu.edu.

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Phosphoprotein CDP138 regulates glucose metabolismR01DK094025 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI JIANG, ZHEN YUE · 2012 to 2016
$1.8M
NCATS NIH HHS UL1 TR001430NIDDK NIH HHS R01 DK094025
6 · The paper itself

Abstract

CDP138 is a calcium- and lipid-binding protein that is involved in membrane trafficking. Here, we report that mice without CDP138 develop obesity under normal chow diet (NCD) or high-fat diet (HFD) conditions. CDP138

Indexed as

Adipose Tissue, BrownAdrenal GlandsAnimalsCatecholaminesCell MembraneDiet, High-FatEnergy MetabolismGene ExpressionHomeodomain ProteinsInsulin ResistanceLipid MetabolismMembrane ProteinsMiceMice, Inbred C57BLMuscle, SkeletalPhosphorylationCatecholaminesHomeodomain ProteinsMembrane ProteinsProto-Oncogene Proteins c-aktSterol EsteraseC2 domain proteincatecholamine releaseCDP138fat browninginsulin resistanceinsulin sensitivitylipolysismembrane transportobesitystress responsesympathetic nerve

Identifiers

PMID29378832
PMCPMC5879461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.