Evidence map›Paper›PMID 29378821›Full record

ArticleG3 (Bethesda, Md.)2018

Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes.

Jessica P Hekman, Jennifer L Johnson, Whitney Edwards, Anastasiya V Vladimirova, Rimma G Gulevich, Alexandra L Ford, Anastasiya V Kharlamova, Yury Herbeck, Gregory M Acland, Lori T Raetzman and 2 more

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jessica P HekmanDepartment of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801 jphekman@arborius.net avk@illinois.edu.ORCID 0000-0002-7296-8307
Jennifer L JohnsonDepartment of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801.
Whitney EdwardsDepartment of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, College of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign, Illinois 61801.
Anastasiya V VladimirovaInstitute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Rimma G GulevichInstitute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Alexandra L FordDepartment of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801.
Anastasiya V KharlamovaInstitute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Yury HerbeckInstitute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Gregory M AclandBaker Institute for Animal Health, Cornell University, College of Veterinary Medicine, Ithaca, New York 14853.
Lori T RaetzmanDepartment of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, College of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign, Illinois 61801.
Lyudmila N TrutInstitute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Anna V KukekovaDepartment of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana-Champaign, Illinois 61801 jphekman@arborius.net avk@illinois.edu.ORCID 0000-0001-7027-3715
University of Illinois Urbana-Champaign · USInstitute of Cytology and Genetics · RUNew York State College of Veterinary Medicine · US

Funding

Research Training Program in Toxicology and Environmental HealthT32ES007326 · NIEHS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Jodi A. Flaws · 2000 to 2026
$8.7M
Notch Signaling Regulates Pituitary OrganogenesisR01DK076647 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RAETZMAN, LORI T · 2007 to 2016
$2.7M
Molecular Mechanisms of Social BehaviorR01GM120782 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KUKEKOVA, ANNA · 2016 to 2019
$1.6M
NIDDK NIH HHS R01 DK076647NIEHS NIH HHS T32 ES007326NIGMS NIH HHS R01 GM120782
6 · The paper itself

Abstract

Domesticated species exhibit a suite of behavioral, endocrinological, and morphological changes referred to as "domestication syndrome." These changes may include a reduction in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and specifically reduced adrenocorticotropic hormone release from the anterior pituitary. To investigate the biological mechanisms targeted during domestication, we investigated gene expression in the pituitaries of experimentally domesticated foxes (

Indexed as

AggressionBehavior, AnimalTranscriptomeAdrenocorticotropic HormoneAlternative SplicingAnimalsComputational BiologyDomesticationFoxesGene Expression ProfilingGene Expression RegulationGene OntologyGene Regulatory NetworksHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPituitary Gland, AnteriorAdrenocorticotropic Hormonedomesticationhypothalamic-pituitary-adrenal axispituitaryRNA-seqVulpes vulpes

Identifiers

PMID29378821
PMCPMC5844307
OpenAlexW2787929658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.