Evidence map›Paper›PMID 29378787›Full record

ArticleGenes & development2018

Widespread transcriptional pausing and elongation control at enhancers.

Telmo Henriques, Benjamin S Scruggs, Michiko O Inouye, Ginger W Muse, Lucy H Williams, Adam B Burkholder, Christopher A Lavender, David C Fargo, Karen Adelman

Abstract read
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 238 papers.

0numbers the graph read from it
0cells of the map it votes in
238citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

238 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. UnlockingNAR genomics and bioinformatics · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Direct roles of long non-coding RNAs in transcription activation.Nature structural & molecular biology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Small RNA Analysis in Cancer Cells.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  19. Article
  20. Review

178 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Telmo HenriquesEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Benjamin S ScruggsEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Michiko O InouyeEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Ginger W MuseEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Lucy H WilliamsEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Adam B BurkholderCenter for Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Christopher A LavenderCenter for Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
David C FargoCenter for Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Karen AdelmanEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

Funding

Investigating Transcriptional Responses to the EnvironmentZ01ES101987 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ADELMAN, KAREN L · 2006 to 2008
$2.8M
Intramural NIH HHS Z01 ES101987
6 · The paper itself

Abstract

Regulation by gene-distal enhancers is critical for cell type-specific and condition-specific patterns of gene expression. Thus, to understand the basis of gene activity in a given cell type or tissue, we must identify the precise locations of enhancers and functionally characterize their behaviors. Here, we demonstrate that transcription is a nearly universal feature of enhancers in

Indexed as

Enhancer Elements, GeneticGene Expression RegulationTranscription Elongation, GeneticAnimalsChromatinChromosomal Proteins, Non-HistoneDrosophilaDrosophila ProteinsEmbryonic Stem CellsHistonesMicePromoter Regions, GeneticRNA Polymerase IIRNA, UntranslatedTranscriptional Elongation FactorsTranscription, GeneticChromatinChromosomal Proteins, Non-HistoneDrosophila ProteinsHistonesRNA Polymerase IIRNA, UntranslatedSPT5 transcriptional elongation factorTranscriptional Elongation FactorsenhancersPol II pausingP-TEFbsuperenhancersterminationtranscription

Identifiers

PMID29378787
PMCPMC5828392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.