Evidence map›Paper›PMID 29378774›Full record

ArticleThe EMBO journal2018

CD1d-mediated lipid presentation by CD11c

Julia Sáez de Guinoa, Rebeca Jimeno, Mauro Gaya, David Kipling, María José Garzón, Deborah Dunn-Walters, Carles Ubeda, Patricia Barral

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Review
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  8. Glycolipids from the gut symbiontChemical science · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Frontiers in immunology · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. The role of T cells in age-related diseases.Nature reviews. Immunology · 2022
    Review
  17. The iNKT Cell-Macrophage Axis in Homeostasis and Disease.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Julia Sáez de GuinoaThe Peter Gorer Department of Immunobiology, King's College London, London, UK.
Rebeca JimenoThe Peter Gorer Department of Immunobiology, King's College London, London, UK.
Mauro GayaRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
David KiplingDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.
María José GarzónDepartamento de Genómica y Salud, Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain.ORCID 0000-0002-9136-1236
Deborah Dunn-WaltersFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Carles UbedaDepartamento de Genómica y Salud, Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain.
Patricia BarralThe Peter Gorer Department of Immunobiology, King's College London, London, UK patricia.barral@kcl.ac.uk.ORCID 0000-0003-4324-8973
King's College London · GBFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESCardiff University · GBRagon Institute of MGH, MIT and Harvard · USUniversity of Surrey · GB

Funding

Medical Research Council MR/L008157/1Medical Research Council MR/L01257X/1Medical Research Council MR/L01257X/2NIAID NIH HHS HHSN272201300006C
6 · The paper itself

Abstract

Intestinal homeostasis relies on a continuous dialogue between the commensal bacteria and the immune system. Natural killer T (NKT) cells, which recognize CD1d-restricted microbial lipids and self-lipids, contribute to the regulation of mucosal immunity, yet the mechanisms underlying their functions remain poorly understood. Here, we demonstrate that NKT cells respond to intestinal lipids and CD11c

Indexed as

AnimalsAntigens, CD1dCD11c AntigenDendritic CellsDysbiosisGastrointestinal MicrobiomeImmunoglobulin AInterleukin-4Intestinal MucosaMacrophagesMembrane LipidsMiceMice, Inbred C57BLMice, KnockoutNatural Killer T-CellsT-Lymphocytes, RegulatoryAntigens, CD1dCD11c AntigenCD1d antigen, mouseImmunoglobulin AInterleukin-4Membrane LipidsCD1dmicrobiotaNKT cell

Identifiers

PMID29378774
PMCPMC5830915
OpenAlexW2787716287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.