ArticleJournal of the American Heart Association2018
Evidence for Pressure-Independent Sympathetic Modulation of Central Pulse Wave Velocity.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03611699 (Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients
Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- The acute effect of passively assisted trunk stretching on central arterial stiffness and blood pressure in middle-aged to older adults.European journal of applied physiology · 2024Trial
- Short-term high sodium intake increases nocturnal blood pressure but not arterial stiffness in Black adults.European journal of nutrition · 2026Article
- Direct causality measures unravel complex networks of cardiovascular dynamics and their modifications with postural stress.PLoS computational biology · 2026Article
- Arterial stiffness in the context of heart rate and vasomotion during orthostatic stress and cognitive load.Frontiers in network physiology · 2026Article
- Association between arterial stiffness and long-term efficacy of renal sympathetic denervation: 5-year results of the ASORAS study.Cardiovascular intervention and therapeutics · 2026Article
- Long working hours at midlife and arterial stiffness at older age in a 24-year prospective cohort.BMC public health · 2025Article
- Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies.Journal of the American Heart Association · 2025Article
- Article
- In silico validation of non-invasive arterial compliance estimation and potential determinants of its variability.Physiological research · 2024Article
- The association of structural versus load-dependent large artery stiffness mechanisms with cerebrovascular damage and cortical atrophy in humans.GeroScience · 2024Article
- Perfusion and pulsatile pressure: their relationship with target organ damage in the African-PREDICT study.BMC cardiovascular disorders · 2024Article
- Sex differences in sympathetic activity and pulse wave velocity in adults with chronic kidney disease.American journal of physiology. Renal physiology · 2024Article
- Assessing High-Order Links in Cardiovascular and Respiratory Networks via Static and Dynamic Information Measures.IEEE open journal of engineering in medicine and biology · 2024Article
- A method to assess linear self-predictability of physiologic processes in the frequency domain: application to beat-to-beat variability of arterial compliance.Frontiers in network physiology · 2024Article
- Association Between Arterial Stiffness and Measures of Autonomic Dysfunction in People With Chronic Kidney Disease.Canadian journal of kidney health and disease · 2023Article
- Serum Catestatin Levels Correlate with Ambulatory Blood Pressure and Indices of Arterial Stiffness in Patients with Primary Hypertension.Biomolecules · 2022Article
- Clinical Applications Measuring Arterial Stiffness: An Expert Consensus for the Application of Cardio-Ankle Vascular Index.American journal of hypertension · 2022Article
- Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences.Physiology (Bethesda, Md.) · 2022Review
- Aortic haemodynamics: the effects of habitual endurance exercise, age and muscle sympathetic vasomotor outflow in healthy men.European journal of applied physiology · 2022Article
- Short-term arterial compliance changes in the context of systolic blood pressure influence.Physiological research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether the sympathetic nervous system can directly alter central aortic stiffness remains controversial, mainly because of the difficulty in experimentally augmenting peripheral vasoconstrictor activity without changing blood pressure. METHODS AND
resultsTo address this limitation, we utilized low-level cardiopulmonary baroreflex loading and unloading shown previously to alter sympathetic outflow without evoking parallel hemodynamic modulation. Blood pressure and carotid-femoral aortic pulse wave velocity (cf-PWV) were measured in 32 healthy participants (24±2 years; women: n=15) before and during 12-minute applications of low-level lower body negative pressure; -7 mm Hg) and lower body positive pressure; +7 mm Hg), applied in a random order. Fibular nerve microneurography was used to collect muscle sympathetic nerve activity (MSNA) in a subset (n=8) to confirm peripheral sympathetic responses. During lower body negative pressure, heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance were not statistically different (all
conclusionsThese findings provide evidence that acute elevations in peripheral sympathetic activity can increase central aortic PWV in young participants independent of a change in distending or pulsatile blood pressure or heart rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.