Evidence map›Paper›PMID 29378708›Full record

Trial reportAntimicrobial agents and chemotherapy2018

A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis.

Lynn E Connolly, Valerie Riddle, Deborah Cebrik, Eliana S Armstrong, Loren G Miller

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01096849 (A Double-blind, Randomized, Comparator-controlled Study to Assess the Safety, Efficacy, and Pharmacokinetics of ACHN-490 Injection Administered IV in Patients With Complicated Urinary Tract Infections or Acute Pyelonephritis), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01096849 phase2completednot on this map

A Double-blind, Randomized, Comparator-controlled Study to Assess the Safety, Efficacy, and Pharmacokinetics of ACHN-490 Injection Administered IV in Patients With Complicated Urinary Tract Infections or Acute Pyelonephritis

TypeinterventionalSponsorAchaogen, Inc.Ran2010 to 2012Enrolled145ConditionsComplicated Urinary Tract Infection, Acute PyelonephritisArmslevofloxacin, plazomicin, placebo
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Carbapenem-ResistantMedicina (Kaunas, Lithuania) · 2024
    Review
  5. Review
  6. Review
  7. Carbohydrate-based drugs launched during 2000Acta pharmaceutica Sinica. B · 2022
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Children.Journal of the Pediatric Infectious Diseases Society · 2020
    Review
  17. Review
  18. Antimicrobial resistance in nephrology.Nature reviews. Nephrology · 2019
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lynn E ConnollyAchaogen, Inc., South San Francisco, California, USA lconnolly@achaogen.com.
Valerie RiddleBioPharmAdvisors LLC, Parrish, Florida, USA.
Deborah CebrikAchaogen, Inc., South San Francisco, California, USA.
Eliana S ArmstrongAchaogen, Inc., South San Francisco, California, USA.
Loren G MillerDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles BioMedical Research at Harbor-UCLA Medical Center, Torrance, California, USA.
University of California, Los Angeles · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

Increasing antimicrobial resistance among uropathogens limits treatment options for patients with complicated urinary tract infection (cUTI). Plazomicin, a new aminoglycoside, has

Indexed as

AdultAminoglycosidesAnti-Bacterial AgentsDouble-Blind MethodFemaleHumansLevofloxacinMaleMiddle AgedPyelonephritisSisomicinUrinary Tract InfectionsYoung AdultAminoglycosidesAnti-Bacterial AgentsLevofloxacinplazomicinSisomicinaminoglycosidesantibacterial therapyclinical trialscomplicated urinary tract infectionplazomicinpyelonephritis

Identifiers

PMID29378708
PMCPMC5913993
OpenAlexW2794429815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.