Evidence map›Paper›PMID 29378656›Full record

ArticleReproductive biology and endocrinology : RB&E2018

Navigation problems of ICSI or naive blastocyst can be solved with artificial blastocyst.

Onder Celik, Mustafa Acet, Haldun Arpaci, Levent Dikbas, Aytac Imren, Bulent Duran, Nilufer Celik, Sudenaz Celik, Cihat Unlu, Ibrahim Sahin and 1 more

Abstract read
In one paragraph

Article in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Onder CelikPrivate Clinic, Obstetrics and Gynecology, Usak, Turkey. celiksudenaz@gmail.com.
Mustafa AcetPrivate Clinic, Obstetrics and Gynecology, Istanbul, Turkey.
Haldun ArpaciDepartment of Obstetrics and Gynecology, Kafkas University School of Medicine, Kars, Turkey.
Levent DikbasDepartment of Obstetrics and Gynecology, Aksaray University School of Medicine, Aksaray, Turkey.
Aytac ImrenDepartment of Obstetrics and Gynecology, Medical Park Hospital, Usak, Turkey.
Bulent DuranAdatip Private Hospital IVF Center, Kocaeli, Turkey.
Nilufer CelikDepartment of Biochemistry, BehcetUz Children's Hospital, Izmir, Turkey.
Sudenaz CelikKent College Guzelbahce High School, Izmir, Turkey.
Cihat UnluAcibadem University School of Medicine Department of Obstetrics and Gynecology, Istanbul, Turkey.
Ibrahim SahinDepartment of Medical Biology Erzincan University, School of Medicine, Erzincan, Turkey.
Suleyman AydinDepartment of Medical Biochemistry (Firat Hormones Research Group), Firat University, School of Medicine, Elazig, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryos have evolved a remarkable capacity to find implantation site. The impressive navigation ability of natural blastocysts may rely on highly sensitive signals arising from embryos and specialized signal processing strategies in the endometrium. Navigation capabilities may be compromised in ICSI embryos because of altered biochemical signaling. The design and delivery of artificial blastocyst (AB) carrying strong chemical signals may allow ICSI embryos to more easily locate to and be retained in the implantation zone. ICSI embryos will attach easily to the implantation zone after it is found by the AB. Co-transfer of the AB together with the ICSI embryo may overcome potential difficulties in implantation due to impaired embryo-maternal communication in cases with implantation failure.

Indexed as

Signal TransductionSperm Injections, IntracytoplasmicChemotactic FactorsChemotaxisEmbryo ImplantationEmbryo TransferFemaleHumansChemotactic Factors

Identifiers

PMID29378656
PMCPMC5789575

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.