ArticleBMC complementary and alternative medicine2018
Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Applications of Traditional Herbal Ingredients in Skincare: Mapping the Research Landscape and Innovation Trajectories Over Four Decades.Journal of cosmetic dermatology · 2025Pooled it
- Development of nanoemulsion formulation loaded with Enteromorpha intestinalis extract: Characterization and evaluation for topical use.PloS one · 2026Article
- Role of Nutritional Elements in Skin Homeostasis: A Review.Biomolecules · 2025Review
- Volatiles from French and Croatian Sea Fennel Ecotypes: Chemical Profiles and the Antioxidant, Antimicrobial and Antiageing Activity of Essential Oils and Hydrolates.Foods (Basel, Switzerland) · 2024Article
- Environmental toxicants and health adversities: A review on interventions of phytochemicals.Journal of public health research · 2023Article
- Article
- Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications.Molecules (Basel, Switzerland) · 2022Review
- Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat.BMC complementary medicine and therapies · 2021Article
- Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage.International journal of molecular sciences · 2020Article
- Identification and Extraction Optimization of Active Constituents inMolecules (Basel, Switzerland) · 2019Article
- Development of aqueous-based multi-herbal combination using principal component analysis and its functional significance in HepG2 cells.BMC complementary and alternative medicine · 2019Article
- Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases.BioMed research international · 2019Review
- Therapeutic Potential of Green Seaweed:Journal of pharmacy & bioallied sciencesArticle
- The efficacy of antiaging cream withJournal of advanced pharmaceutical technology & researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the skin. Extrinsic factors that affect skin aging such as UV radiation can also cause malignant melanoma. Here we selected four medicinal plant materials, namely, leaves of Nyctanthes arbor-tristis, unripe and ripe Aegle marmelos fruit pulp and the terminal meristem of Musa paradisiaca flower and investigated their anti-aging properties and cytotoxicity in vitro individually as well as in a poly herbal formulation containing the four plant extracts in different ratios.
methodsThe phytochemical contents of the plant extracts were investigated for radical scavenging activity and total reducing power. Based upon its anti-oxidant properties, a poly herbal formulation containing leaves of Nyctanthes arbor-tristis, unripe and ripe fruit pulp of Aegle marmelos, and the terminal meristem of Musa paradisiaca flower in the ratio 6:2:1:1 (Poly Herbal Formulation 1) and 1:1:1:1 (Poly Herbal Formulation 2), respectively were formulated.
resultIt has been observed that the Poly Herbal Formulation 1 was more potent than Poly Herbal Formulation 2 due to better anti-oxidant and anti-elastase activities in NIH3T3 fibroblast cells. In addition Poly Herbal formulation 1 also had better anti-cancer activity in human malignant melanoma cells.
conclusionBased on these results these beneficial plant extracts were identified for its potential application as an anti-aging agent in skin creams as well as an anti-proliferation compound against cancer cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.