ArticleDiagnostic pathology2018
Treponema pallidum Immunohistochemistry is positive in human intestinal Spirochetosis.
Article in Diagnostic pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human intestinal spirochetosis, irritable bowel syndrome, and colonic polyps: A systematic review and meta-analysis.Journal of gastroenterology and hepatology · 2022Pooled it
- The Basophilic Fringe: A Case Report of Intestinal Spirochetosis in a Patient With Chronic Diarrhea.Cureus · 2026Article
- Syphilitic Cholangiopathy Mimicking Primary Sclerosing Cholangitis.Infectious disease reports · 2025Article
- Clinical characteristics ofFrontiers in cellular and infection microbiology · 2025Article
- A Case Study: Incidental Finding of Human Intestinal Spirochetosis in Screening Colonoscopy.Cureus · 2024Article
- Host individual and gut location are more important in gut microbiota community composition than temporal variation in the marine herbivorous fish Kyphosus sydneyanus.BMC microbiology · 2023Article
- Article
- Laboratory Diagnostic Tools for Syphilis: Current Status and Future Prospects.Frontiers in cellular and infection microbiology · 2020Review
- Treponema pallidum Immunohistochemistry is positive in human intestinal Spirochetosis.Diagnostic pathology · 2018Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman intestinal spirochetosis (IS) has been recognized for decades, but whether it represents commensalism or a pathogenic process remains controversial. IS is diagnosed on routine stains with confirmation by silver stains but these stains are labor intensive and slow to read. We evaluated the Treponema pallidum immunostain as a diagnostic adjunct for IS.
methodsWe retrieved biopsies from 33 patients with IS for this study. Each case was tested by Warthin-Starry (WS) and T. pallidum immunohistochemistry (IHC). Species specific genotyping was performed in 3 cases.
resultsPatients with IS ranged from 22 to 82 years without gender predilection. IS involved normal (n = 15), and inflamed (n = 5) mucosa and colonic polyps (n = 13). Warthin-Starry and T. pallidum IHC were positive in all cases including both species of Brachyspira. Six (18%) symptomatic patients were treated for IS, and experienced resolution. In patients diagnosed with incidental IS on cancer screening (n = 5), follow up biopsies, without therapy, were negative for IS. T. pallidum IHC required 75 min less hands-on time than WS for performance and was faster to interpret.
conclusionsT. pallidum IHC can be used to confirm the diagnosis of IS and is easier to perform and faster to interpret than WS.
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