ArticleBMC veterinary research2018
Cortisol modulates inflammatory responses in LPS-stimulated RAW264.7 cells via the NF-κB and MAPK pathways.
Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Brain inflammation and its predictive value for post-operative pain in total knee arthroplasty patients.Brain, behavior, and immunity · 2025Article
- Cortisol prevents the suppressive effect of LPS on bovine oocyte maturation in vitro.The Journal of reproduction and development · 2025Article
- Inhibitory effects of AptaminC320 targeting vitamin C on LPS-induced inflammation in RAW264.7 cells.Biochemistry and biophysics reports · 2025Article
- Study on the therapeutic effect of Viola yedoensis and Leonurus japonicus on bovine endometritis.Journal of animal science · 2025Article
- Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024Review
- JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions.Molecular biomedicine · 2023Review
- Chitooligosaccharide from Pacific White Shrimp Shell Chitosan Ameliorates Inflammation and Oxidative Stress via NF-κB, Erk1/2, Akt and Nrf2/HO-1 Pathways in LPS-Induced RAW264.7 Macrophage Cells.Foods (Basel, Switzerland) · 2023Article
- Effects of combined cannabidiol (CBD) and hops (Humulus lupulus) terpene extract treatment on RAW 264.7 macrophage viability and inflammatory markers.Natural products and bioprospecting · 2023Article
- Synthetic Glabridin Derivatives Inhibit LPS-Induced Inflammation via MAPKs and NF-κB Pathways in RAW264.7 Macrophages.Molecules (Basel, Switzerland) · 2023Article
- Extracellular Vesicles, as Drug-Delivery Vehicles, Improve the Biological Activities of Astaxanthin.Antioxidants (Basel, Switzerland) · 2023Article
- siRNA-MediatedInternational journal of molecular sciences · 2023Article
- Article
- Bioactivity-guided isolation of anti-inflammatory limonins fromFood science & nutrition · 2022Article
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- Comparison of the in vitro Anti-Inflammatory Effect of Cannabidiol to Dexamethasone.Clinical, cosmetic and investigational dermatology · 2022Article
- Effects ofFrontiers in pharmacology · 2022Article
- Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells.Molecules (Basel, Switzerland) · 2021Article
- Promising Antiviral Activity ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Antibacterial, Immunomodulatory, and Lung Protective Effects ofAntibiotics (Basel, Switzerland) · 2021Article
- Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe uteruses of most dairy cattle are easily infected by bacteria, especially gram-negative bacteria, following parturition. Macrophages are important cells of the immune system and play a critical role in the inflammatory response. In addition, cortisol levels become significantly increased due to the stress of parturition in dairy cattle, and cortisol is among the most widely used and effective therapies for many inflammatory diseases. In this study, we assessed the anti-inflammatory effects and potential molecular mechanisms of cortisol using a Lipopolysaccharide (LPS)-induced RAW264.7 macrophage cell line.
resultsCortisol significantly suppressed the production of prostaglandin E
conclusionsThese results suggest that high cortisol levels can attenuate LPS-induced inflammatory responses in the RAW264.7 macrophage cell line by regulating the NF-κB and MAPK signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.