ArticleBMC microbiology2018
Detection and genotyping of Helicobacter pylori in saliva versus stool samples from asymptomatic individuals in Northeastern Thailand reveals intra-host tissue-specific H. pylori subtypes.
Article in BMC microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Oral Helicobacter pylori: a scoping review and pilot study on the PCR-culture detection paradox.Clinical oral investigations · 2026Article
- Extraoral Detection of Biomarkers and Pathogens in Saliva: Comprehensive, Panoramic Review.Biosensors · 2026Review
- Site-stratified global oralJournal of oral microbiology · 2026Review
- Application value and performance of stool antigen detection in the diagnosis of Helicobacter pylori infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Poor Oral Hygiene: A Hidden Risk Factor for Helicobacter pylori Infection.International dental journal · 2025Article
- A rapid and accurate method forFrontiers in cellular and infection microbiology · 2025Article
- Helicobacter pylori in oral cavity: current knowledge.Clinical and experimental medicine · 2024Review
- Diagnostic Methods for Helicobacter pylori.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Review
- Molecular characterization of Helicobacter pylori isolated from Nile Tilapia (Oreochromis niloticus) and fish handlers.BMC veterinary research · 2023Article
- Association between the presence and genotype ofExperimental and therapeutic medicine · 2023Article
- Frequency and risk factors of H. pylori infection among dental students: an observational cross-sectional study.Scientific reports · 2023Observational
- Analysis of Genetic Relatedness between Gastric and OralInternational journal of molecular sciences · 2023Article
- Are molecular methods helpful for the diagnosis ofFrontiers in microbiology · 2022Article
- Rapid and Sensitive Assay ofFrontiers in microbiology · 2022Article
- Intracellular Presence ofMicroorganisms · 2021Article
- Changes in the fecal microbiome of the Yangtze finless porpoise during a short-term therapeutic treatment.Open life sciences · 2020Article
- AsymptomaticNutrients · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTwo-thirds of the world's population is thought to be infected by Helicobacter pylori. Although most people infected with H. pylori are asymptomatic, this pathogen is associated with several gastric pathologies including cancer. The risk factors for colonization are still unclear and the genetic diversity within individual hosts has never been clearly investigated.
resultThis study determined the prevalence of, and explored risk factors for, H. pylori infection directly from paired saliva (n = 110) and stool (n = 110) samples from asymptomatic persons in Northeast Thailand. Samples were subjected to indirect immunofluorescence assay (IFA), 16S rRNA-based real-time PCR and vacA-based semi-nested PCR. Partial vacA gene sequences of H. pylori were compared between saliva and stool samples. The overall prevalence of H. pylori infection in our asymptomatic study population was 64%. Age, gender, occupation and frequency of brushing teeth were not found to be associated with H. pylori colonization. The vacA gene was successfully sequenced from both saliva and stool samples of 12 individuals. For seven of these individuals, saliva and stool sequences fell into different clusters on a phylogenetic tree, indicating intra-host genetic variation of H. pylori.
conclusionThis study reports a high prevalence of H. pylori infection in asymptomatic persons in this region of Thailand and demonstrates that genotypes (vacA gene sequences) of H. pylori may differ between the oral cavity and intestinal tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.