ArticleBMC genomics2018
Integrated ovarian mRNA and miRNA transcriptome profiling characterizes the genetic basis of prolificacy traits in sheep (Ovis aries).
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Genome-Wide Identification, Evolutionary Analysis and Seasonal Expression Patterns of the Sox Gene Family in the Daurian Ground Squirrel (Veterinary sciences · 2026Article
- Selection signatures on the autosomes and the X chromosome in the prolific Belclare sheep breed.Veterinary and animal science · 2026Article
- Integrated multi-omics profiling unveils a network of key signaling pathways governing ovarian function and systemic regulation in high-prolificacy goats.BMC genomics · 2026Article
- An Ovine Intestinal Organoid-Macrophage Co-Culture Model to Test the Effects of Ovine Colostrum Exosomes on Intestinal Barrier Function and Inflammation.International journal of molecular sciences · 2025Article
- Oar_Finn: the genome assembly and annotation of an exceptionally fertile Finnsheep (Ovis aries) Ewe.BMC genomic data · 2025Article
- Effect of different fermentation substrates on rumen microorganisms and microbe-derived extracellular vesicles (EVs).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations.Science China. Life sciences · 2025Review
- Genome-wide association study reveals candidate genes for litter size and function validation ofFrontiers in veterinary science · 2025Article
- Integration of multi-omics reveals the important role of the BBS10 gene in reproduction.Journal of animal science · 2024Article
- Expression profiles of circulating miRNAs in an endangered Piedmontese sheep breed during the estrus cycle.Frontiers in veterinary science · 2024Article
- Comprehensive Analysis of Differentially Expressed CircRNAs in the Ovaries of Low- and High-Fertility Sheep.Animals : an open access journal from MDPI · 2023Article
- Comparative expression analysis of water buffalo (Frontiers in veterinary science · 2023Article
- High-Altitude Stress Orchestrates mRNA Expression and Alternative Splicing of Ovarian Follicle Development Genes in Tibetan Sheep.Animals : an open access journal from MDPI · 2022Article
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- The Roles of the miRNAome and Transcriptome in the Ovine Ovary Reveal Poor Efficiency in Juvenile Superovulation.Animals : an open access journal from MDPI · 2021Article
- Multi-Omics Approach Reveals miR-SNPs Affecting Muscle Fatty Acids Profile in Nelore Cattle.Genes · 2021Article
- Hypothalamic Transcriptome Analysis Reveals the Crucial MicroRNAs and mRNAs Affecting Litter Size in Goats.Frontiers in veterinary science · 2021Article
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Authors and funding
11 authors.
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Abstract
backgroundThe highly prolific breeds of domestic sheep (Ovis aries) are globally valuable genetic resources for sheep industry. Genetic, nutritional and other environmental factors affect prolificacy traits in sheep. To improve our knowledge of the sheep prolificacy traits, we conducted mRNA-miRNA integrated profiling of ovarian tissues from two pure breeds with large (Finnsheep) vs. small (Texel) litter sizes and their F1 crosses, half of which were fed a flushing diet.
resultsAmong the samples, 16,402 genes (60.6% known ovine genes) were expressed, 79 novel miRNAs were found, and a cluster of miRNAs on chromosome 18 was detected. The majority of the differentially expressed genes between breeds were upregulated in the Texel with low prolificacy, owing to the flushing diet effect, whereas a similar pattern was not detected in the Finnsheep. F1 ewes responded similarly to Finnsheep rather than displaying a performance intermediate between the two pure breeds.
conclusionsThe identification and characterization of differentially expressed genes and miRNAs in the ovaries of sheep provided insights into genetic and environmental factors affecting prolificacy traits. The three genes (CST6, MEPE and HBB) that were differentially expressed between the group of Finnsheep and Texel ewes kept in normal diet appeared to be candidate genes of prolificacy traits and will require further validation.
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