ArticleNucleic acids research2018
i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Polyamines are i-motif disruptors.Molecular therapy. Nucleic acids · 2026Article
- APE1 binds and processes abasic sites present in i-motif DNA and cooperates with PCBP1 in maintenance of telomeric stability.Nucleic acids research · 2026Article
- QuaDB: A streamlined web tool for identifier-based rapid prediction of putative quadruplex sequences.Human genomics · 2026Article
- Spectroscopic studies of sequence-dependent conformational transitions in asymmetric G/C rich double-stranded DNA.European biophysics journal : EBJ · 2025Article
- Twisting tetraplex DNA: A strand dynamics regulating i-motif function in diverse molecular crowding environments.Nucleic acids research · 2025Article
- An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids.ACS nano · 2024Article
- Shedding Light on the Photophysics and Photochemistry of I-Motifs Using Quantum Mechanical Calculations.International journal of molecular sciences · 2023Article
- A Synthetic Signaling Network Imitating the Action of Immune Cells in Response to Bacterial Metabolism.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- DNA i-motif formation at neutral pH is driven by kinetic partitioning.Nucleic acids research · 2023Article
- An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer.International journal of molecular sciences · 2020Review
- Molecular Spectroscopic Markers of DNA Damage.Molecules (Basel, Switzerland) · 2020Review
- Epigenetic modification of cytosines fine tunes the stability of i-motif DNA.Nucleic acids research · 2020Article
- Systematic investigation of sequence requirements for DNA i-motif formation.Nucleic acids research · 2019Article
- i-Motif DNA: structural features and significance to cell biology.Nucleic acids research · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
i-Motif (iM) is a four stranded DNA structure formed by cytosine-rich sequences, which are often present in functionally important parts of the genome such as promoters of genes and telomeres. Using electronic circular dichroism and UV absorption spectroscopies and electrophoretic methods, we examined the effect of four naturally occurring DNA base lesions on the folding and stability of the iM formed by the human telomere DNA sequence (C3TAA)3C3T. The results demonstrate that the TAA loop lesions, the apurinic site and 8-oxoadenine substituting for adenine, and the 5-hydroxymethyluracil substituting for thymine only marginally disturb the formation of iM. The presence of uracil, which is formed by enzymatic or spontaneous deamination of cytosine, shifts iM formation towards substantially more acidic pH values and simultaneously distinctly reduces iM stability. This effect depends on the position of the damage sites in the sequence. The results have enabled us to formulate additional rules for iM formation.
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