ArticleJournal of experimental botany2018
Autophagy controls resource allocation and protein storage accumulation in Arabidopsis seeds.
Article in Journal of experimental botany, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 81 citations in OpenAlex.
- Beyond degradation: Dissecting autophagy-protease relationships in plant reproduction.Plant reproduction · 2026Review
- Raffinose induces autophagy to promote the growth of Arabidopsis Thaliana.BMC plant biology · 2025Article
- Functional Analysis of the Autophagy-Related GenePlants (Basel, Switzerland) · 2025Article
- Review
- Towards resilience: Transcriptional insights on flavonoid biosynthesis during peanut seed maturation phases.PloS one · 2025Article
- A tissue-specific rescue strategy reveals the local roles of autophagy in leaves and seeds for resource allocation.Plant physiology · 2024Article
- Full-length transcriptome sequencing of Arabidopsis plants provided new insights into the autophagic regulation of photosynthesis.Scientific reports · 2024Article
- Lon1 Inactivation Downregulates Autophagic Flux and Brassinosteroid Biogenesis, Modulating Mitochondrial Proportion and Seed Development inInternational journal of molecular sciences · 2024Article
- Autophagy maintains endosperm quality during seed storage to preserve germination ability in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Autophagy: A New Avenue and Biochemical Mechanisms to Mitigate the Climate Change.Scientifica · 2024Review
- Studying plant autophagy: challenges and recommended methodologies.Advanced biotechnology · 2023Review
- Role of autophagy-related proteins ATG8f and ATG8h in the maintenance of autophagic activity inFrontiers in plant science · 2023Article
- Genome-wide analysis revealed the stepwise origin and functional diversification of HSDs from lower to higher plant species.Frontiers in plant science · 2023Article
- A View into Seed Autophagy: From Development to Environmental Responses.Plants (Basel, Switzerland) · 2022Article
- Review
- Autophagy in the Lifetime of Plants: From Seed to Seed.International journal of molecular sciences · 2022Review
- The ubiquitin-26S proteasome system and autophagy relay proteome homeostasis regulation during silique development.The Plant journal : for cell and molecular biology · 2022Article
- Exploring the Contribution of Autophagy to the Excess-Sucrose Response inInternational journal of molecular sciences · 2022Article
- Autophagy modulates the metabolism and growth of tomato fruit during development.Horticulture research · 2022Article
- Multiscale imaging reveals the presence of autophagic vacuoles in developing maize endosperm.Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy is essential for nutrient recycling and plays a fundamental role in seed production and grain filling in plants. Autophagy participates in nitrogen remobilization at the whole-plant level, and the seeds of autophagy mutants present abnormal C and N contents relative to wild-type (WT) plants. It is well known that autophagy (ATG) genes are induced in leaves during senescence; however, expression of such genes in seeds has not yet been reported. In this study we show that most of the ATG genes are induced during seed maturation in Arabidopsis siliques. Promoter-ATG8f::UIDA and promoter-ATG8f::GFP fusions showed the strong expression of ATG8f in the phloem companion cells of pericarps and the funiculus, and in the embryo. Expression was especially strong at the late stages of development. The presence of many GFP-ATG8 pre-autophagosomal structures and autophagosomes confirmed the presence of autophagic activity in WT seed embryos. Seeds of atg5 and WT plants grown under low- or high-nitrate conditions were analysed. Nitrate-independent phenotypes were found with higher seed abortion in atg5 and early browing, higher total protein concentrations in the viable seeds of this mutant as compared to the WT. The higher total protein accumulation in atg5 viable seeds was significant from early developmental stages onwards. In addition, relatively low and early accumulation of 12S globulins were found in atg5 seeds. These features led us to the conclusion that atg5 seed development is accelerated and that the protein storage deposition pathway is somehow abnormal or incomplete.
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