ArticleIEEE transactions on biomedical circuits and systems2018
1024-Pixel CMOS Multimodality Joint Cellular Sensor/Stimulator Array for Real-Time Holistic Cellular Characterization and Cell-Based Drug Screening.
Article in IEEE transactions on biomedical circuits and systems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A Dual-Mode Neural Amplifier Array for Biopotential and FSCV-Based Neurochemical Measurements.Biosensors · 2026Article
- Microfluidic platforms for monitoring cardiomyocyte electromechanical activity.Microsystems & nanoengineering · 2025Review
- A 512-Ch Dual-Mode Microchip for Simultaneous Measurements of Electrophysiological and Neurochemical Activities.Biosensors · 2023Article
- Impedance Imaging of Cells and Tissues: Design and Applications.BME frontiers · 2022Article
- Oral Cells-On-Chip: Design, Modeling and Experimental Results.Bioengineering (Basel, Switzerland) · 2022Article
- Advances in non-invasive biosensing measures to monitor wound healing progression.Frontiers in bioengineering and biotechnology · 2022Review
- The Design of a CMOS Nanoelectrode Array with 4096 Current-Clamp/Voltage-Clamp Amplifiers for Intracellular Recording/Stimulation of Mammalian Neurons.IEEE journal of solid-state circuits · 2020Article
- Intracellular cardiomyocytes potential recording by planar electrode array and fibroblasts co-culturing on multi-modal CMOS chip.Biosensors & bioelectronics · 2019Article
- High-Density Electrical Recording and Impedance Imaging With a Multi-Modal CMOS Multi-Electrode Array Chip.Frontiers in neuroscience · 2019Article
- Single-Cell Recording of Vesicle Release From Human Neuroblastoma Cells Using 1024-ch Monolithic CMOS Bioelectronics.IEEE transactions on biomedical circuits and systems · 2018Article
- Multi-parametric cell profiling with a CMOS quad-modality cellular interfacing array for label-free fully automated drug screening.Lab on a chip · 2018Article
- Sensing Cell-Culture Assays with Low-Cost Circuitry.Scientific reports · 2018Article
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Authors and funding
8 authors.
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Abstract
This paper presents a fully integrated CMOS multimodality joint sensor/stimulator array with 1024 pixels for real-time holistic cellular characterization and drug screening. The proposed system consists of four pixel groups and four parallel signal-conditioning blocks. Every pixel group contains 16 × 16 pixels, and each pixel includes one gold-plated electrode, four photodiodes, and in-pixel circuits, within a pixel footprint. Each pixel supports real-time extracellular potential recording, optical detection, charge-balanced biphasic current stimulation, and cellular impedance measurement for the same cellular sample. The proposed system is fabricated in a standard 130-nm CMOS process. Rat cardiomyocytes are successfully cultured on-chip. Measured high-resolution optical opacity images, extracellular potential recordings, biphasic current stimulations, and cellular impedance images demonstrate the unique advantages of the system for holistic cell characterization and drug screening. Furthermore, this paper demonstrates the use of optical detection on the on-chip cultured cardiomyocytes to real-time track their cyclic beating pattern and beating rate.
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