Evidence map›Paper›PMID 29377772›Full record

ArticleHuman vaccines & immunotherapeutics2018

Assessment of mumps-containing vaccine effectiveness during an outbreak: Importance to introduce the 2-dose schedule for China.

Chao Ma, Yan Liu, Jihai Tang, Haimei Jia, Wei Qin, Ying Su, Huaqing Wang, Lixin Hao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Vaccines for measles, mumps, rubella, and varicella in children.The Cochrane database of systematic reviews · 2020
    Pooled it
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  19. Attenuated MuV-S79 as vector stably expressing foreign gene.World journal of pediatrics : WJP · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chao Maa Department of National Immunization Program , Chinese Center for Disease Control and Prevention , Beijing , China.
Yan Liub Department of Expanded Program on Immunization , Hangzhou Center for Disease Control and Prevention , Hangzhou , China.
Jihai Tangd Department of Expanded Program on Immunization , Anhui Center for Disease Control and Prevention , Hefei , China.
Haimei Jiac Chinese Epidemiology Training Program, Chinese Center for Disease Control and Prevention , Beijing , China.
Wei Qinf Department of Expanded Program on Immunization , Lu'an Center for Disease Control and Prevention , Lu'an , China.
Ying Sud Department of Expanded Program on Immunization , Anhui Center for Disease Control and Prevention , Hefei , China.
Huaqing Wanga Department of National Immunization Program , Chinese Center for Disease Control and Prevention , Beijing , China.
Lixin Haoa Department of National Immunization Program , Chinese Center for Disease Control and Prevention , Beijing , China.
Chinese Center For Disease Control and Prevention · CNAnhui Provincial Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChina has used 3 different mumps-containing vaccines (MuCV) since 1990: monovalent mumps vaccine, measles-mumps (MM) vaccine, and measles-mumps-rubella (MMR) vaccine, and one dose MuCV (using MMR at 18 months) has been included in the EPI since 2007. MuCV effectiveness has been of concern following large-scale mumps outbreaks. In 2015, an outbreak of mumps occurred in a primary school, which allow us assess vaccine effectiveness of different MuCVs.

methodAll children in the school were studied as a retrospective cohort. Vaccination histories and case information were obtained from vaccination records and clinic/hospital logs. Parental questionnaires were used to confirm students' illnesses and calculate attack rate (AR). VE was assessed using the formula, VE = (AR in unvaccinated students- AR in the vaccinated students) / (AR in unvaccinated students). VEs of different type of MuCV were compared.

resultsIn total, 283 students were identified as clinical mumps among the 2370 students, and 1908 students were included for MuCV VE assessment. 213 (including 21 [8.9%] patients) were 2-dose MuCV recipients (AR: 9.9%), 1165 (including 123 [51.9%] patients) were 1-dose recipients (AR: 10.6%), and 530 (including 93 [39.2%] patients) were unvaccinated (AR: 17.5%). VE was 44% for 2 doses and 40% for one dose. For one-MuCV-dose students, estimated mumps VE was 63% for vaccinated within 3 years (between vaccination and this outbreak); 50% for vaccinated within 3 to 5 years; and 34% for vaccinated more than 5 years. Comparing VE by vaccine type and 5-year interval since vaccination, VE for MMR was 60%, which was consistently higher than VE for monovalent mumps vaccine (22%) and MM (2%).

conclusionThis outbreak was associated with low and declining 1-dose MuCV effectiveness. China's immunization program should evaluate the potential of a 2-dose MMR schedule to adequately control mumps.

Indexed as

Disease OutbreaksImmunization ScheduleAdolescentChildChinaDisease Transmission, InfectiousFemaleHumansMaleMumpsMumps VaccineRetrospective StudiesSurveys and QuestionnairesTreatment OutcomeMumps VaccineChinaeffectivenessMumpsschedulevaccine

Identifiers

PMID29377772
PMCPMC6037455
OpenAlexW2794178191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.