Evidence map›Paper›PMID 29377709›Full record

SynthesisJournal of alternative and complementary medicine (New York, N.Y.)2018

Physicochemical Investigations of Homeopathic Preparations: A Systematic Review and Bibliometric Analysis-Part 1.

Sabine D Klein, Sandra Würtenberger, Ursula Wolf, Stephan Baumgartner, Alexander Tournier

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of alternative and complementary medicine (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Subcutaneous application ofFrontiers in public health · 2026
    Observational
  4. Article
  5. Interactions of Highly DilutedInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
  8. Highly Diluted Glyphosate Mitigates Its Effects onInternational journal of molecular sciences · 2023
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sabine D Klein1 Institute of Complementary Medicine, University of Bern , Bern, Switzerland .
Sandra Würtenberger2 Scientific & Regulatory Affairs, Hevert-Arzneimittel GmbH & Co. KG , Nussbaum, Germany .
Ursula Wolf1 Institute of Complementary Medicine, University of Bern , Bern, Switzerland .
Stephan Baumgartner1 Institute of Complementary Medicine, University of Bern , Bern, Switzerland .
Alexander Tournier1 Institute of Complementary Medicine, University of Bern , Bern, Switzerland .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe last systematic review of physicochemical research performed on homeopathic preparations was published in 2003. The aim of the study is to update and expand the current state of knowledge in the area of physicochemical properties of homeopathic preparations. In part 1 of the study, we aim to present an overview of the literature with respect to publication quality and methods used. In part 2, we aim to identify the most interesting experimental techniques. With this, we aim to be in a position to generate meaningful hypotheses regarding a possible mode of action of homeopathic preparations.

methodsA two-step procedure was adopted: (1) an extensive literature search, followed by a bibliometric and quality analysis on the level of publications and (2) a thorough qualitative analysis of the individual physicochemical investigations found. In this publication, we report on step (1). We searched major scientific databases to find publications reporting physicochemical investigations of homeopathy from its origin to the end of 2015. Publications were assessed using a scoring scheme, the Manuscript Information Score (MIS). Information regarding country of origin of the research and experimental techniques used was extracted.

resultsWe identified 183 publications (compared to 44 in the last review), 122 of which had an MIS ≥5. The rate of publication in the field was ∼2 per year from the 1970s until 2000. Afterward, it increased to over 5.5 publications per year. The quality of publications was seen to increase sharply from 2000 onward, whereas before 2000, only 12 (13%) publications were rated as "high quality" (MIS ≥7.5); 44 (48%) publications were rated as "high quality" from 2000 onward. Countries with most publications were Germany (n = 42, 23%), France (n = 29, 16%), India (n = 27, 15%), and Italy (n = 26, 14%). Techniques most frequently used were electrical impedance (26%), analytical methods (20%), spectroscopy (20%), and nuclear magnetic resonance (19%).

conclusionsPhysicochemical research into homeopathic preparations is increasing both in terms of quantity and quality of the publications.

Indexed as

BibliometricsHomeopathyMateria MedicaMateria Medicahomeopathyphysicsserially diluted and agitated solutionssystematic reviewultrahigh aqueous dilutionsvery high dilutions

Identifiers

PMID29377709
PMCPMC5961874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.