Evidence map›Paper›PMID 29377589›Full record

ArticleJournal of biomedical materials research. Part A2018

Nitric oxide-releasing antibacterial albumin plastic for biomedical applications.

Alexander Jones, Jitendra Pant, Eliza Lee, Marcus J Goudie, Alexey Gruzd, Joel Mansfield, Abhyuday Mandal, Suraj Sharma, Hitesh Handa

Abstract read
In one paragraph

Article in Journal of biomedical materials research. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexander JonesDepartment of Textiles, Merchandising and Interiors, University of Georgia, Athens, Georgia.
Jitendra PantSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.
Eliza LeeDepartment of Textiles, Merchandising and Interiors, University of Georgia, Athens, Georgia.
Marcus J GoudieSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.
Alexey GruzdDepartment of Textiles, Merchandising and Interiors, University of Georgia, Athens, Georgia.
Joel MansfieldSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.
Abhyuday MandalDepartment of Statistics, University of Georgia, Athens, Georgia.
Suraj SharmaDepartment of Textiles, Merchandising and Interiors, University of Georgia, Athens, Georgia.
Hitesh HandaSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.

Funding

Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
Prevention of Thrombosis by NO Secreting PolymersK25HL111213 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANDA, HITESH · 2012 to 2016
$739k
NHLBI NIH HHS K25 HL111213NHLBI NIH HHS R01 HL134899
6 · The paper itself

Abstract

Designing innovative materials for biomedical applications is desired to prevent surface fouling and risk of associated infections arising in the surgical care patient. In the present study, albumin plastic was fabricated and nitric oxide (NO) donor, S-nitroso-N-acetylpenicillamine (SNAP), was incorporated through a solvent swelling process. The albumin-SNAP plastic was evaluated in terms of mechanical and thermal properties, and bacterial adhesion to the plastic surface. Thermal and viscoelastic analyses showed no significant difference between albumin-SNAP plastics and pure, water-plasticized albumin samples. Bacteria adhesion tests revealed that albumin-SNAP plastic can significantly reduce the surface-bound viable gram-positive Staphylococcus aureus and gram-negative Pseudomonas aeruginosa bacterial cells by 98.7 and 98.5%, respectively, when compared with the traditional polyvinyl chloride medical grade tubing material. The results from this study demonstrate NO-releasing albumin plastic's potential as a material for biomedical device applications. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1535-1542, 2018.

Indexed as

AlbuminsBacterial AdhesionBacterial InfectionsBiocompatible MaterialsEquipment and SuppliesHumansNitric Oxide DonorsPlasticsPseudomonas aeruginosaS-Nitroso-N-AcetylpenicillamineStaphylococcus aureusAlbuminsBiocompatible MaterialsNitric Oxide DonorsPlasticsS-Nitroso-N-Acetylpenicillaminealbumin plasticdevice-associated infectionsnitric oxideS-nitroso-N-acetylpenicillamine

Identifiers

PMID29377589
PMCPMC9680931

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.