Evidence map›Paper›PMID 29377273›Full record

ArticleClinical transplantation2018

Increasing kidney donor profile index sequence does not adversely affect medium-term health-related quality of life after kidney transplantation.

Rachel C Forbes, Irene D Feurer, David LaNeve, Beatrice P Concepcion, Christianna Gamble, Scott A Rega, C Wright Pinson, David Shaffer

Abstract read
In one paragraph

Article in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rachel C ForbesDepartment of Surgery, Division of Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-6827-791X
Irene D FeurerDepartments of Surgery and Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
David LaNeveVanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Beatrice P ConcepcionDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA.
Christianna GambleVanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Scott A RegaVanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, TN, USA.
C Wright PinsonVanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, TN, USA.
David ShafferDepartment of Surgery, Division of Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243
6 · The paper itself

Abstract

backgroundThe United Network for Organ Sharing system allocates deceased donor kidneys based on the kidney donor profile index (KDPI), stratified as sequences (A ≤ 20%, B > 20-<35%, C ≥ 35-≤85%, and D > 85%), with increasing KDPI associated with decreased graft survival. While health-related quality of life (HRQOL) may improve after transplantation, the effect of donor kidney quality, reflected by KDPI sequence, on post-transplant HRQOL has not been reported.

methodsHealth-related quality of life was measured using the eight scales and physical and mental component summaries (PCS, MCS) of the SF-36

resultsA total of 141 waitlisted adults and 505 recipients (>1700 observations) were included. Pretransplant PCS and MCS averaged, respectively, slightly below and within general population norms (GPN; 40-60). At 31 ± 26 months post-transplant, average PCS (41 ± 11) and MCS (51 ± 11), overall and within each KDPI sequence, were within GPN. KDPI sequence was not related to post-transplant HRQOL (P > .134) or its trajectory (interaction P > .163).

conclusionIncreasing KDPI does not adversely affect the medium-term values and trajectories of HRQOL after kidney transplantation. This may reassure patients and centers when considering using high KDPI kidneys.

Indexed as

Donor SelectionQuality of LifeFemaleFollow-Up StudiesGraft SurvivalHumansKidney Failure, ChronicKidney TransplantationLongitudinal StudiesMaleMiddle AgedPrognosisTissue and Organ ProcurementTissue DonorsTransplant Recipientshealth-related quality of lifeKDPIkidney allocation systemkidney transplantationorgan utilization

Identifiers

PMID29377273
PMCPMC5933873
OpenAlexW2792165865

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.