Evidence map›Paper›PMID 29377202›Full record

ReviewAnnals of the New York Academy of Sciences2018

Update on management of diabetic foot ulcers.

Estelle Everett, Nestoras Mathioudakis

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 358 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
358citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03890172 unknown statusnot on this mapstarted 2019, after this paper: background citation

Efficacy of Platelets Rich Plasma as a Therapeutic Tool in Chronic Non Healing Diabetic Foot Ulcers

TypeobservationalSponsorAssiut UniversityRan2019 to 2021Enrolled60ConditionsDiabetic Foot UlcerArms20-100 ml venous blood will be drawn the from patient into sterilized centrifuge tube ,following centrifuge to separate PRP and at the bed side and tricked onto the ulcer twice weekly, standard treatment
NCT05076955 early_phase1unknown statusnot on this mapstarted 2021, after this paper: background citation

Evaluating the Healing of Diabetic Foot Ulcers With Compounded Anti-Infective Irrigation

TypeinterventionalSponsorUniversity of Mississippi Medical CenterRan2021 to 2022Enrolled100ConditionsDiabetic Foot UlcerArmsvancomycin-tobramycin-itraconazole
NCT07488247 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

Single-Centre, Open-labeled, Randomized, Phase IIb and Phase III Clinical Studies to Evaluate the Safety, Tolerability, and Efficacy of Chlorin E6 (Gel Formation) as a Photosensitizing Agent for the Management of Diabetic Foot Ulcers With Photodynamic Therapy.

TypeinterventionalSponsorUnited Medical and Dental CollegeRan2026 to 2027Enrolled300ConditionsDiabetic Foot Ulcer (DFU)ArmsChlorin E6 Gel
3 · Its place in the literature

Who cites it

358 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  6. Procalcitonin and Diabetic Foot Ulcer Infections: A Meta-Analysis.Endocrinology, diabetes & metabolism · 2025
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298 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Estelle EverettDivision of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Nestoras MathioudakisDivision of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-0210-655X

Funding

Clinical Research&Epidemiology in Diabetes&EndocrinologyT32DK062707 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Wendy Lynet Bennett · 2002 to 2026
$7.3M
Cardiometabolic Health in Adolescents of South Asian Ancestry - the CHAriSmA studyR01DK115648 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MAGGE, SHEELA NATESH · 2018 to 2022
$3.9M
NIDDK NIH HHS R01 DK115648NIDDK NIH HHS T32 DK062707
6 · The paper itself

Abstract

Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. These practices are best coordinated by a multidisciplinary diabetic foot wound clinic. Even with this comprehensive approach, there is still room for improvement in DFU outcomes. Several adjuvant therapies have been studied to reduce DFU healing times and amputation rates. We reviewed the rationale and guidelines for current standard of care practices and reviewed the evidence for the efficacy of adjuvant agents. The adjuvant therapies reviewed include the following categories: nonsurgical debridement agents, dressings and topical agents, oxygen therapies, negative pressure wound therapy, acellular bioproducts, human growth factors, energy-based therapies, and systemic therapies. Many of these agents have been found to be beneficial in improving wound healing rates, although a large proportion of the data are small, randomized controlled trials with high risks of bias.

Indexed as

Amputation, SurgicalAnti-Bacterial AgentsBandagesCombined Modality TherapyDebridementDiabetic FootHumansHyperbaric OxygenationHypoglycemic AgentsIntercellular Signaling Peptides and ProteinsMicrobial CollagenaseNegative-Pressure Wound TherapyPatient Care TeamPeripheral Arterial DiseasePhysical Therapy ModalitiesPractice Guidelines as TopicAnti-Bacterial AgentsHypoglycemic AgentsIntercellular Signaling Peptides and ProteinsMicrobial Collagenasediabetesdiabetic foot managementdiabetic foot ulcerswound healing

Identifiers

PMID29377202
PMCPMC5793889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.