Evidence map›Paper›PMID 29377106›Full record

ArticleFEBS letters2018

Modulation of GSK3β autoinhibition by Thr-7 and Thr-8.

Yixin Tong, Sohyun Park, Di Wu, Thurl E Harris, Christopher A Moskaluk, David L Brautigan, Zheng Fu

Open access · bronzeAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yixin TongDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Sohyun ParkDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Di WuDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Thurl E HarrisDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Christopher A MoskalukDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
David L BrautiganDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
Zheng FuDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
University of Virginia · USTongji Hospital · CN

Funding

Signaling Mechanisms and Cellular Functions of a Ciliopathy-Associated Protein KinaseR01GM127690 · NIGMS · UNIVERSITY OF VIRGINIA · PI Zheng Fu · 2018 to 2026
$2.4M
Role of Oxidized neutral lipids in adipocyte functionR01DK101946 · NIDDK · UNIVERSITY OF VIRGINIA · PI HARRIS, THURL E. · 2014 to 2018
$1.7M
Oncogenic role of the ICK-GSK3beta signaling pathwayR21CA195273 · NCI · UNIVERSITY OF VIRGINIA · PI FU, ZHENG · 2016 to 2017
$378k
NCI NIH HHS R21 CA195273NIDDK NIH HHS R01 DK101946NIGMS NIH HHS R01 GM127690
6 · The paper itself

Abstract

Glycogen synthase kinase 3β (GSK-3β) is a pivotal signaling node that regulates a myriad of cellular functions and is deregulated in many pathological conditions, making it an attractive therapeutic target. Inhibitory Ser-9 phosphorylation of GSK3β by AKT is an important mechanism for negative regulation of GSK3β activity upon insulin stimulation. Here, we report that Thr-7 and Thr-8 residues located in the AKT/PKB substrate consensus sequence on GSK3β are essential for insulin-stimulated Ser-9 phosphorylation in vivo and for GSK3β inactivation. Intestinal cell kinase (ICK) phosphorylates GSK3β Thr-7 in vitro and in vivo. Thr-8 phosphorylation partially inhibits GSK3β, but Thr-7 phosphorylation promotes GSK3β activity and blocks phospho-Ser-9-dependent GSK3β autoinhibition. Our findings uncover novel mechanistic and signaling inputs involved in the autoinhibition of GSK3β.

Indexed as

Amino Acid SequenceAnimalsGlycogen Synthase Kinase 3 betaHEK293 CellsHumansInsulinPhosphorylationProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktThreonineCILK1 protein, humanGlycogen Synthase Kinase 3 betaInsulinProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktThreonineAKTautoinhibitionGSK3βICKinsulinphosphorylation

Identifiers

PMID29377106
PMCPMC5829016
OpenAlexW2791097098

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.