ArticleJournal of biomedical nanotechnology2017
Effect of Nanoparticle Surface Coating on Cell Toxicity and Mitochondria Uptake.
Article in Journal of biomedical nanotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Nanoparticle-Enabled Modulation of the Bone Immune Microenvironment for Enhanced Regeneration.Bioengineering (Basel, Switzerland) · 2026Review
- Engineered MoSNanomaterials (Basel, Switzerland) · 2026Review
- N-Doped Graphene for Biomedical Applications: A Comparative Biocompatibility Assessment of Green and Chemical Exfoliation.Chemical research in toxicology · 2025Article
- Surface Charge Affects the Intracellular Fate and Clearance Dynamics of CdSe/ZnS Quantum Dots in Macrophages.Nanomaterials (Basel, Switzerland) · 2025Article
- Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes.Nanomaterials (Basel, Switzerland) · 2023Review
- SiOMolecules (Basel, Switzerland) · 2022Article
- One-Step Aqueous Synthesis of Anionic and Cationic AgInSInorganic chemistry · 2022Article
- Liposomal delivery of CRISPR/Cas9.Cancer gene therapy · 2020Review
- Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine.Nano-micro letters · 2020Review
- In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quantum Dots with Different Surface Modifications.International journal of nanomedicine · 2020Article
- Cardiotoxicity of Intravenously Administered CdSe/ZnS Quantum Dots in BALB/c Mice.Frontiers in pharmacology · 2019Article
- Recent Advances in Mitochondria-Targeted Gene Delivery.Molecules (Basel, Switzerland) · 2018Review
- Cytotoxicity of InP/ZnS Quantum Dots With Different Surface Functional Groups Toward Two Lung-Derived Cell Lines.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We report on the effect of surface charge and the ligand coating composition of CdSe/ZnS core/shell quantum dot (QD) nanoparticles on human keratinocyte toxicity using fluorescent microscopy, flow cytometry, transmission electron microscopy. Two commonly reported positive charged (cysteamine, polyethylenimine) and two negative charged (glutathione, dihydrolipoic acid) ligands were studied. The QDs were fully characterized by UV-vis absorption spectroscopy, fluorescence emission spectroscopy, dynamic light scattering and zeta potential. Differences in surface coatings and charges were evaluated against cellular uptake, ROS generation, cytotoxicity, and mitochondrial targeting. Results show that the negative charged QDs coated with GSH exhibit excellent water solubility, high quantum yield and low cytotoxicity. Ligand composition is more important in ROS generation than surface charge whereas surface charge is an important driver of cytotoxicity. Most importantly we observe the selective accumulation of glutathione coated QDs in vesicles in the mitochondria matrix. This observation suggests a new strategy for developing mitochondria-targeted nanomaterials for drug/gene delivery.
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Registered trials
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