Evidence map›Paper›PMID 29377002›Full record

ArticleNature chemical biology2018

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation.

Marie Couturier, Simon Ladevèze, Gerlind Sulzenbacher, Luisa Ciano, Mathieu Fanuel, Céline Moreau, Ana Villares, Bernard Cathala, Florence Chaspoul, Kristian E Frandsen and 12 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
21.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 333 citations in OpenAlex.

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  17. The disordered C-terminal tail of fungal LPMOs from phytopathogens mediates protein dimerization and impacts plant penetration.Proceedings of the National Academy of Sciences of the United States of America · 2024
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 3 countries.

Marie CouturierINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.
Simon LadevèzeINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.
Gerlind SulzenbacherArchitecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille University, Marseille, France.ORCID 0000-0003-4844-2820
Luisa CianoDepartment of Chemistry, University of York, York, UK.ORCID 0000-0002-1667-0856
Mathieu FanuelINRA, Unité de Recherche Biopolymères Interactions Assemblages (BIA), Nantes, France.
Céline MoreauINRA, Unité de Recherche Biopolymères Interactions Assemblages (BIA), Nantes, France.
Ana VillaresINRA, Unité de Recherche Biopolymères Interactions Assemblages (BIA), Nantes, France.
Bernard CathalaINRA, Unité de Recherche Biopolymères Interactions Assemblages (BIA), Nantes, France.
Florence ChaspoulIMBE Aix Marseille University, IRD CNRS UAPV, Faculté de Pharmacie, Marseille, France.
Kristian E FrandsenINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.
Aurore LabourelINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.
Isabelle Herpoël-GimbertINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.
Sacha GriselINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.
Mireille HaonINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.
Nicolas LenfantArchitecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille University, Marseille, France.
Hélène RogniauxINRA, Unité de Recherche Biopolymères Interactions Assemblages (BIA), Nantes, France.
David RopartzINRA, Unité de Recherche Biopolymères Interactions Assemblages (BIA), Nantes, France.
Gideon J DaviesDepartment of Chemistry, University of York, York, UK.ORCID 0000-0002-7343-776X
Marie-Noëlle RossoINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.
Paul H WaltonDepartment of Chemistry, University of York, York, UK.ORCID 0000-0002-1152-1480
Bernard HenrissatArchitecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille University, Marseille, France.
Jean-Guy BerrinINRA, Aix Marseille University, Biodiversité et Biotechnologie Fongiques (BBF), Marseille, France.ORCID 0000-0001-7570-3745
Aix-Marseille Université · FRBiopolymères Interactions Assemblages · FRCentre National de la Recherche Scientifique · FRUniversity of York · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wood biomass is the most abundant feedstock envisioned for the development of modern biorefineries. However, the cost-effective conversion of this form of biomass into commodity products is limited by its resistance to enzymatic degradation. Here we describe a new family of fungal lytic polysaccharide monooxygenases (LPMOs) prevalent among white-rot and brown-rot basidiomycetes that is active on xylans-a recalcitrant polysaccharide abundant in wood biomass. Two AA14 LPMO members from the white-rot fungus Pycnoporus coccineus substantially increase the efficiency of wood saccharification through oxidative cleavage of highly refractory xylan-coated cellulose fibers. The discovery of this unique enzyme activity advances our knowledge on the degradation of woody biomass in nature and offers an innovative solution for improving enzyme cocktails for biorefinery applications.

Indexed as

BiomassBasidiomycotaBiodegradation, EnvironmentalBiotechnologyCelluloseComputational BiologyCost-Benefit AnalysisCrystallography, X-RayElectron Spin Resonance SpectroscopyGenomicsGlycosylationMixed Function OxygenasesOxygenPhylogenyPolysaccharidesSubstrate SpecificityCelluloseMixed Function OxygenasesOxygenPolysaccharidesXylans

Identifiers

PMID29377002
OpenAlexW2785833536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.