Evidence map›Paper›PMID 29376872›Full record

ArticleJournal of Alzheimer's disease : JAD2018

Characteristics of Cognitively Normal Mexican-Americans with Cognitive Complaints.

James R Hall, April Wiechmann, Leigh A Johnson, Melissa Edwards, Sid E O'Bryant

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

James R HallCenter for Alzheimer's and Neurodegenerative Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA.
April WiechmannDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
Leigh A JohnsonInstitute for Health Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Melissa EdwardsDepartment of Psychology, University of North Texas, Denton, TX, USA.
Sid E O'BryantInstitute for Health Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
University of North Texas Health Science Center · USUniversity of North Texas · US

Funding

Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
Proinflammatory Endophenotype to predict NSAID treatment response Alzheimer's trialsR01AG051848 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LYKETSOS, CONSTANTINE G, O'BRYANT, SID E · 2016 to 2020
$3.7M
NIA NIH HHS R01 AG051848NIA NIH HHS R01 AG054073
6 · The paper itself

Abstract

backgroundSubjective cognitive complaints in cognitively normal adults have been linked to later cognitive decline and dementia. Research on the characteristics of this group has been conducted on a variety of clinical and community-based populations. The current study focuses on the rapidly expanding population of Mexican-American elders.

objectiveThe objective of the study is the determination of characteristics of cognitively normal Mexican-Americans with cognitive complaints.

methodsData on 319 cognitively normal participants in a large-scale community-based study of elderly Mexican-Americans (HABLE) were analyzed comparing those with cognitive complaints with those without on clinical characteristics, affective status, neuropsychological functioning, and proteomic markers.

resultsThose expressing concern about cognitive decline scored lower on the MMSE, were more likely to have significantly more affective symptoms, higher levels of diabetic markers, poorer performance on attention and executive functioning, and a different pattern of inflammatory markers.

conclusionAlthough longitudinal research is needed to determine the impact of these differences on later cognition, possible targets for early intervention with Mexican-Americans were identified.

Indexed as

Mexican AmericansAgedBiomarkersCognitionCognitive DysfunctionExecutive FunctionFemaleHumansMaleMiddle AgedNeuropsychological TestsRisk FactorsTexasBiomarkersAffective symptomsbiomarkersMexican-Americanssubjective cognitive complaints

Identifiers

PMID29376872
PMCPMC13270985
OpenAlexW2791735721

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.