Evidence map›Paper›PMID 29376464›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia.

Andrew N Clarkson, Lily Boothman-Burrell, Zita Dósa, Raghavendra Y Nagaraja, Liang Jin, Kim Parker, Petra S van Nieuwenhuijzen, Silke Neumann, Emma K Gowing, Navnath Gavande and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Methyl Derivatives of Flavone as Potential Anti-Inflammatory Compounds.International journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  7. The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  8. Targeting GABABrain sciences · 2021
    Article
  9. Sodium butyrate attenuated neuronal apoptosis via GPR41/Gβγ/PI3K/Akt pathway after MCAO in rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  10. Review
  11. Article
  12. Review
  13. Antioxidant Therapies for Neuroprotection-A Review.Journal of clinical medicine · 2019
    Review
  14. Article
  15. The Delta-Subunit Selective GABAFrontiers in neuroscience · 2019
    Article
  16. Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Andrew N Clarkson1 Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
Lily Boothman-Burrell1 Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
Zita Dósa3 Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Raghavendra Y Nagaraja1 Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
Liang Jin4 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Kim Parker1 Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
Petra S van Nieuwenhuijzen2 Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
Silke Neumann1 Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
Emma K Gowing1 Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
Navnath Gavande2 Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
Philip K Ahring2 Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
Mai M Holm3 Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Jane R Hanrahan2 Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
Joseph A Nicolazzo4 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Kimmo Jensen3 Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Mary Chebib2 Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
University of Sydney · AUBrain Research New Zealand · NZAarhus University · DKMonash University · AUUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tonic inhibitory currents, mediated by extrasynaptic GABA

Indexed as

AnimalsBrainBrain IschemiaDisease Models, AnimalFlavonesGABA ModulatorsMaleMiceMice, Inbred BALB CMice, KnockoutNeuroprotective AgentsReceptors, GABA-AStrokeSynaptic Potentials2'-methoxy-6-methylflavoneFlavonesGABA ModulatorsNeuroprotective AgentsReceptors, GABA-Ainflammationmotor behaviourPhotothrombotic stroketonic inhibitionγ-aminobutyric acid

Identifiers

PMID29376464
PMCPMC6668512
OpenAlexW2794009533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.