Evidence map›Paper›PMID 29376397›Full record

ArticleAutism : the international journal of research and practice2019

Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development.

Eric Rubenstein, Lisa D Wiggins, Laura A Schieve, Chyrise Bradley, Carolyn DiGuiseppi, Eric Moody, Juhi Pandey, Rebecca Edmondson Pretzel, Annie Green Howard, Andrew F Olshan and 2 more

Abstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Sensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  10. Examining the Relationship Between Parental Broader Autism Phenotype Traits, Offspring Autism, and Parental Mental Health.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Autistic-Like Traits in Members of the General Population and Mate Retention Tactics: The Mediation of Attachment Styles and Reproductive Strategies.Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eric Rubenstein1 University of North Carolina at Chapel Hill, USA.ORCID 0000-0002-9146-4497
Lisa D Wiggins2 Centers for Disease Control and Prevention, USA.
Laura A Schieve2 Centers for Disease Control and Prevention, USA.
Chyrise Bradley1 University of North Carolina at Chapel Hill, USA.
Carolyn DiGuiseppi3 University of Colorado-Anschutz Medical Campus, USA.
Eric Moody3 University of Colorado-Anschutz Medical Campus, USA.
Juhi Pandey4 Children's Hospital of Philadelphia, USA.
Rebecca Edmondson Pretzel1 University of North Carolina at Chapel Hill, USA.
Annie Green Howard1 University of North Carolina at Chapel Hill, USA.
Andrew F Olshan1 University of North Carolina at Chapel Hill, USA.
Brian W Pence1 University of North Carolina at Chapel Hill, USA.
Julie Daniels1 University of North Carolina at Chapel Hill, USA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Centers for Autism & Develop Disabilities Resarch & Epidemiol:A Case-Cohort StudyU10DD000183 · DD · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE · 2006 to 2010
$8.2M
Component A: NC Study to Explore Early Development Phase 3 (SEED 3)U01DD001205 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2016 to 2020
$6.4M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBINSON, MICHAEL BYRNE · 2016 to 2020
$6.3M
National CADDRE Study: Child Development and AutismU10DD000182 · DD · UNIVERSITY OF PENNSYLVANIA · PI PINTO-MARTIN, JENNIFER A · 2006 to 2010
$5.8M
National CADDRE Study: Child Development and AutismU10DD000181 · DD · KAISER FOUNDATION RESEARCH INSTITUTE · PI CROEN, LISA A · 2006 to 2010
$5.6M
Colorado CADDRE: A Case-Cohort StudyU10DD000180 · DD · COLORADO STATE DEPT/PUB HLTH & ENVIRONMT · PI MILLER, LISA ANN · 2006 to 2010
$5.1M
North Carolina Ctr for Autism & Development Disabilities Research & EpidemiologyU10DD000184 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2006 to 2010
$4.7M
Component A: CADDRE: Study to Explore Early Development (SEED) 3U01DD001210 · DD · UNIVERSITY OF COLORADO DENVER · PI ROBINSON, CORDELIA · 2016 to 2020
$3.8M
Data Coordinating Center for Autism & Other DisabilitiesU01DD000498 · DD · MICHIGAN STATE UNIVERSITY · PI REED, PHILIP L · 2009 to 2011
$2.3M
Intramural CDC HHS CC999999NCBDD CDC HHS U01 DD000498NCBDD CDC HHS U01 DD001205NCBDD CDC HHS U01 DD001210NCBDD CDC HHS U10 DD000180NCBDD CDC HHS U10 DD000184NICHD NIH HHS P2C HD050924NICHD NIH HHS U54 HD086984NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research.

Indexed as

EndophenotypesAdultAutism Spectrum DisorderChild, PreschoolCognitionDevelopmental DisabilitiesEmotional RegulationFemaleHumansLanguage Development DisordersLatent Class AnalysisMaleMotor Skills DisordersParentsPhenotypeautism spectrum disorderbroader autism phenotypeendophenotypessubgrouping

Identifiers

PMID29376397
PMCPMC6027594

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.