ArticleThe journal of physical chemistry letters2018
Probing Charge Transport through Peptide Bonds.
Article in The journal of physical chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Enhanced electronic coupling in tetraaryl molecular junctions with osmium(iv) centers.Chemical science · 2026Article
- Scanning Tunneling Microscope-Based Break-Junction TechniqueA Tutorial.ACS physical chemistry Au · 2026Article
- Phosphorylation-Dependent Charge Transport in Biomolecular Junctions of Major Histocompatibility Complex Phosphopeptides.The journal of physical chemistry. B · 2026Article
- Single-Molecule Electron Transport in Peptoids.The journal of physical chemistry. B · 2026Article
- DNA-Guided Robust Single-Protein Electronic Readout.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Too Fast for Spin Flipping: Absence of Chirality-Induced Spin Selectivity in Coherent Electron Transport through Single-Molecule Junctions.Journal of the American Chemical Society · 2025Article
- Single-Molecule Conductance of Staffanes.Angewandte Chemie (International ed. in English) · 2025Article
- Shape-persistent ladder molecules exhibit nanogap-independent conductance in single-molecule junctions.Nature chemistry · 2024Article
- Low Vapor Pressure Solvents for Single-Molecule Junction Measurements.Nano letters · 2024Article
- Secondary structure determines electron transport in peptides.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Coherent spin transport in a copper protein.Journal of molecular modeling · 2024Article
- Charge Transport Across Dynamic Covalent Chemical Bridges.Nano letters · 2022Article
- Constrained DFT for Molecular Junctions.Nanomaterials (Basel, Switzerland) · 2022Article
- Ubiquitous Electron Transport in Non-Electron Transfer Proteins.Life (Basel, Switzerland) · 2020Review
- Article
- Electronic Decay Length in a Protein Molecule.Nano letters · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
We measure the conductance of unmodified peptides at the single-molecule level using the scanning tunneling microscope-based break-junction method, utilizing the N-terminal amine group and the C-terminal carboxyl group as gold metal-binding linkers. Our conductance measurements of oligoglycine and oligoalanine backbones do not rely on peptide side-chain linkers. We compare our results with alkanes terminated asymmetrically with an amine group on one end and a carboxyl group on the other to show that peptide bonds decrease the conductance of an otherwise saturated carbon chain. Using a newly developed first-principles approach, we attribute the decrease in conductance to charge localization at the peptide bond, which reduces the energy of the frontier orbitals relative to the Fermi energy and the electronic coupling to the leads, lowering the tunneling probability. Crucially, this manifests as an increase in conductance decay of peptide backbones with increasing length when compared with alkanes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.