ArticleBioengineering & translational medicine2018
Visible light crosslinkable human hair keratin hydrogels.
Article in Bioengineering & translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Spatiotemporally programmed tissue regeneration via visible-light-responsive hydrogels: Biosafety-oriented design and applications.Materials today. Bio · 2026Review
- Article
- One-Step Tunable Human Hair Keratin Gradient Hydrogel with Antibacterial Activity for Tissue Engineering.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- A novel nanocomposite containing zinc ferrite nanoparticles embedded in carboxymethylcellulose hydrogel plus carbon nitride nanosheets with multifunctional bioactivity.RSC advances · 2023Article
- Hydrogels as functional components in artificial cell systems.Nature reviews. Chemistry · 2022Review
- Engineering Hydrogels for the Development of Three-Dimensional In Vitro Models.International journal of molecular sciences · 2022Review
- Recent advances in engineering hydrogels for niche biomimicking and hematopoietic stem cell culturing.Frontiers in bioengineering and biotechnology · 2022Review
- Poultry Feather Waste as Bio-Based Cross-Linking Additive for Ethylene Propylene Diene Rubber.Polymers · 2021Article
- Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications.Bioactive materials · 2021Review
- Chemically Modified Biopolymers for the Formation of Biomedical Hydrogels.Chemical reviews · 2021Review
- Review
- Development of a Multi-Layer Skin Substitute Using Human Hair Keratinic Extract-Based Hybrid 3D Printing.Polymers · 2021Article
- Keratin - Based materials for biomedical applications.Bioactive materials · 2020Review
- Article
- Hydrogels in the clinic.Bioengineering & translational medicine · 2020Review
- Composite Hydrogels in Three-DimensionalFrontiers in bioengineering and biotechnology · 2020Review
- Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review.Polymers · 2019Review
- Editorial: The launch phase ofBioengineering & translational medicine · 2019Article
- Thiol-Mediated Chemoselective Strategies forGels (Basel, Switzerland) · 2018Review
- A Perspective on 3D Bioprinting in Tissue Regeneration.Bio-design and manufacturing · 2018Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Keratins extracted from human hair have emerged as a promising biomaterial for various biomedical applications, partly due to their wide availability, low cost, minimal immune response, and the potential to engineer autologous tissue constructs. However, the fabrication of keratin-based scaffolds typically relies on limited crosslinking mechanisms, such as via physical interactions or disulfide bond formation, which are time-consuming and result in relatively poor mechanical strength and stability. Here, we report the preparation of photocrosslinkable keratin-polyethylene glycol (PEG) hydrogels via the thiol-norbornene "click" reaction, which can be formed within one minute upon irradiation of visible light. The resulting keratin-PEG hydrogels showed highly tunable mechanical properties of up to 45 kPa in compressive modulus, and long-term stability in buffer solutions and cell culture media. These keratin-based hydrogels were tested as cell culture substrates in both two-dimensional surface seeding and three-dimensional cell encapsulation, demonstrating excellent cytocompatibility to support the attachment, spreading, and proliferation of fibroblast cells. Moreover, the photocrosslinking mechanism makes keratin-based hydrogel suitable for various microfabrication techniques, such as micropatterning and wet spinning, to fabricate cell-laden tissue constructs with different architectures. We believe that the unique features of this photocrosslinkable human hair keratin hydrogel promise new opportunities for their future biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.