ArticleAnnals of clinical and translational neurology2018
Neuronal activity and outcomes from thalamic surgery for spinocerebellar ataxia.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Detecting rhythmic spiking through the power spectra of point process model residuals.Journal of neural engineering · 2024Article
- Detecting rhythmic spiking through the power spectra of point process model residuals.bioRxiv : the preprint server for biology · 2024Article
- Tremor in Spinocerebellar Ataxia: A Scoping Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Case Report: Deep brain stimulation improves tremor inFrontiers in neurology · 2022Article
- An Overview of the Current State and the Future of Ataxia Treatments.Neurologic clinics · 2020Review
- Ataxia.Continuum (Minneapolis, Minn.) · 2019Review
- The Cerebellar Thalamus.Cerebellum (London, England) · 2019Review
- Deep cerebellar stimulation reduces ataxic motor symptoms in the shaker rat.Annals of neurology · 2019Article
- The Comprehensive Management of Cerebellar Ataxia in Adults.Current treatment options in neurology · 2019Review
- SCA2 presenting as a focal dystonia.Journal of clinical movement disorders · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: We investigated the effects of deep brain stimulation (DBS) or lesions of the ventral intermediate nucleus (Vim) of the thalamus for spinocerebellar ataxia (SCA) and examined the pathophysiological role of neuronal activity of the Vim underlying ataxia. Methods: Five patients with SCA with cortical atrophy (ages 60-69 years; 2 sporadic and three familial SCA) and five patients with essential tremor (ET) (ages 57-71 years) were treated with Vim surgery. Intraoperatively, we recorded neuronal activity from single neurons in the Vim thalamus while patients were at rest and compared the physiological properties of those neurons between patients with SCA and those with ET. Results: Postsurgery mean scores for the Fahn-Tolosa-Marin Tremor Scale were improved from 78 to 44 in SCA patients and from 54 to 21 in ET patients. Stronger stimulation was necessary to optimize outcomes in SCA as compared to ET patients. We analyzed 68 Vim neurons in SCA and 60 Vim neurons in ET. Mean discharge rates, burst characteristics, and oscillatory activity were similar for both patient groups, however, we observed that the ratio of cells responding to passive manipulation was significantly smaller ( Interpretation: Thalamic surgery led to a significant improvement in tremor in SCA patients. One potential mechanism underlying ataxia in SCA may be disruption of cerebellar sensory feedback, which modulates motor commands in the cerebello-thalamo-cortical network.
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Registered trials
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