ArticleAnnals of clinical and translational neurology2018
Cognitive impairment in epilepsy: the role of reduced network flexibility.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Evaluating the task-specificity model of verbal memory: Regional volumetric analyses in temporal lobe epilepsy with hippocampal sclerosis.Epilepsia open · 2026Article
- Brain-Pupil Coupling Revealed Through Deep Learning of Intracranial Recordings.Human brain mapping · 2025Article
- Memory compromise at extended delays in people with new-onset epilepsy.Epilepsia open · 2024Article
- Abnormalities of regional brain activity and executive function in patients with temporal lobe epilepsy: A cross-sectional and longitudinal resting-state functional MRI study.Neuroradiology · 2024Article
- Cognitive and psychological dysfunction is present after a first seizure, prior to epilepsy diagnosis and treatment at a First Seizure Clinic.Epilepsia open · 2024Article
- Abnormal white matter structural network topological property in patients with temporal lobe epilepsy.CNS neuroscience & therapeutics · 2024Article
- Resting-state functional MRI study of conventional MRI-negative intractable epilepsy in children.Frontiers in human neuroscience · 2024Article
- Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- Dehydroepiandrosterone Attenuates Astroglial Activation, Neuronal Loss and Dendritic Degeneration in Iron-Induced Post-Traumatic Epilepsy.Brain sciences · 2023Article
- Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Psychophysiological interaction analysis for the detection of stimulus-specific networks in reflex epilepsy.Epilepsia open · 2022Article
- Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Which clinical and neuropsychological factors are responsible for cognitive impairment in patients with epilepsy?International journal of public health · 2020Article
- Aberrant functional connectivity of the cingulate subregions in right-sided temporal lobe epilepsy.Experimental and therapeutic medicine · 2020Article
- Impaired vigilance networks in temporal lobe epilepsy: Mechanisms and clinical implications.Epilepsia · 2020Review
- Identifying Mild Hepatic Encephalopathy Based on Multi-Layer Modular Algorithm and Machine Learning.Frontiers in neuroscience · 2020Article
- Alterations Functional Connectivity in Temporal Lobe Epilepsy and Their Relationships With Cognitive Function: A Longitudinal Resting-State fMRI Study.Frontiers in neurology · 2020Article
- Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.Neuropsychiatric disease and treatment · 2020Article
- Altered intrinsic brain activity associated with outcome in frontal lobe epilepsy.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The dominant model of cognitive impairment in focal epilepsy has emphasised structural bases for cognitive deficits. Current theories of cognition in the healthy brain emphasise the importance of the reweighting of brain network interactions in support of task performance. Here, we explore the hypothesis that cognitive deficits in epilepsy arise through abnormalities of dynamic functional network interactions. Method: We studied 19 healthy controls and 37 temporal lobe epilepsy (TLE) patients, using a behavioural measure of verbal fluency (the Controlled Oral Word Association Test) and an fMRI verbal fluency paradigm (Orthographic Lexical Retrieval). Results: Behaviourally, verbal fluency was significantly impaired in TLE. Psychophysiological interaction analyses of the fMRI data, which capture state-dependent changes in network connectivity, revealed reduced task-dependent modulations of connectivity from left superior medial frontal cortex to left middle frontal gyrus in TLE patients. Individual differences in verbal fluency among TLE cases was correlated with task-dependent changes in connectivity from left posterior cingulate to left superior medial frontal cortex, and from left superior medial frontal cortex to a range of right predominant brain areas. Interpretation: These data reveal that the typical pattern of task-driven shifts in network connectivity is not observed in TLE. Our observations go beyond simple structure-function associations and suggest that failure of network flexibility can be an important contributor to cognitive impairment in epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.