Evidence map›Paper›PMID 29376089›Full record

ArticleAnnals of clinical and translational neurology2018

MRI biomarkers of proximal nerve injury in CIDP.

Thorsten Lichtenstein, Alina Sprenger, Kilian Weiss, Karin Slebocki, Barbara Cervantes, Dimitrios Karampinos, David Maintz, Gereon R Fink, Tobias D Henning, Helmar C Lehmann

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  5. [Diagnostic workup for polyneuropathy].Schmerz (Berlin, Germany) · 2024
    Review
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  18. Length-dependent MRI of hereditary neuropathy with liability to pressure palsies.Annals of clinical and translational neurology · 2020
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Thorsten LichtensteinInstitute of Diagnostic and Interventional Radiology University Hospital of Cologne Cologne Germany.
Alina SprengerDepartment of Neurology University Hospital of Cologne Cologne Germany.
Kilian WeissInstitute of Diagnostic and Interventional Radiology University Hospital of Cologne Cologne Germany.
Karin SlebockiInstitute of Diagnostic and Interventional Radiology University Hospital of Cologne Cologne Germany.
Barbara CervantesCognitive Neuroscience Institute of Diagnostic and Interventional Radiology Technical University Munich Munich Germany.
Dimitrios KarampinosCognitive Neuroscience Institute of Diagnostic and Interventional Radiology Technical University Munich Munich Germany.
David MaintzInstitute of Diagnostic and Interventional Radiology University Hospital of Cologne Cologne Germany.
Gereon R FinkDepartment of Neurology University Hospital of Cologne Cologne Germany.
Tobias D HenningInstitute of Diagnostic and Interventional Radiology University Hospital of Cologne Cologne Germany.
Helmar C LehmannDepartment of Neurology University Hospital of Cologne Cologne Germany.
University Hospital Cologne · DETechnical University of Munich · DEForschungszentrum Jülich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the utility of nerve diffusion tensor imaging (DTI), nerve cross-sectional area, and muscle magnetic resonance imaging (MRI) multiecho Dixon for assessing proximal nerve injury in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: In this prospective observational cohort study, 11 patients with CIDP and 11 healthy controls underwent a multiparametric MRI protocol with DTI of the sciatic nerve and assessment of muscle proton-density fat fraction of the biceps femoris and the quadriceps femoris muscles by multiecho Dixon MRI. Patients were longitudinally evaluated by MRI, clinical examination, and nerve conduction studies at baseline and after 6 months. Results: In sciatic nerves of CIDP patients, mean cross-sectional area was significantly higher and fractional anisotropy value was significantly lower, compared to controls. In contrast, muscle proton-density fat fraction was significantly higher in thigh muscles of patients with CIDP, compared to controls. MRI parameters showed high reproducibility at baseline and 6 months. Interpretation: Advanced MRI parameters demonstrate subclinical proximal nerve damage and intramuscular fat accumulation in CIDP. Data suggest DTI and multiecho Dixon MRI might be useful in estimating axonal damage and neurogenic muscle changes in CIDP.

Identifiers

PMID29376089
PMCPMC5771316
OpenAlexW2774412006

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.