ArticleJournal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent2018
Clinical Utility of Screening for Anxiety and Depression in Children with Tourette Syndrome.
Article in Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study.Nutrients · 2022Trial
- Psychiatric Comorbidity, Tic Severity and Quality of Life in Adults with Tourette's Syndrome.Movement disorders clinical practice · 2026Article
- The effect of calendar month on tic severity in children and youth with Tourette syndrome.BJPsych open · 2026Article
- Clinical Features, Mechanisms, and Management of Anxiety in Youth with Tic Disorders: A Narrative Review.Neuropsychiatric disease and treatment · 2026Review
- Challenging current diagnostic and classification criteria for primary tic disorders.European child & adolescent psychiatry · 2025Article
- All-Cause Mortality and Suicide Mortality in Patients With Tic Disorder: An Entire Population Longitudinal Study in Taiwan.Suicide & life-threatening behavior · 2025Article
- Unpacking Tourette Syndrome in Children: Insights into Prevalence and Comorbidities from NSCH Data.Journal of clinical medicine · 2025Article
- Relationship Between Anxiety Symptoms and Age-Related Differences in Tic Severity.Neuropsychiatric disease and treatment · 2025Article
- Addressing co-occurring conditions in behavioural therapy for tic disorders: a review and guideline.European child & adolescent psychiatry · 2024Review
- A Comprehensive Review of Tic Disorders in Children.Journal of clinical medicine · 2021Review
- Anxiety Symptoms Differ in Youth With and Without Tic Disorders.Child psychiatry and human development · 2021Article
- Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Effect of Jian-Pi-Zhi-Dong Decoction on the Amino Acid Neurotransmitters in a Rat Model of Tourette Syndrome and Comorbid Anxiety Disorder.Frontiers in psychiatry · 2020Article
- Current Status, Diagnosis, and Treatment Recommendation for Tic Disorders in China.Frontiers in psychiatry · 2020Review
- Refractory Gilles de la Tourette Syndrome-Many Pieces That Define the Puzzle.Frontiers in neurology · 2020Review
- Effects of comorbidity on Tourette's tic severity and quality of life.Acta neurologica Scandinavica · 2019Article
- Assessment and Management of Tic Disorders in Pediatric Primary Care Settings.Current developmental disorders reports · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTourette syndrome (TS) is often co-morbid with attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). Studies of TS, anxiety and depression have found variable results depending on study methodology and sample characteristics. Our aim was to examine the clinical utility of routine screening for anxiety and depression in children with TS.
methodsUsing a clinic-based sample, we evaluated the proportion of children with TS meeting diagnostic criteria for ADHD, OCD, generalized anxiety disorder (GAD), separation anxiety disorder (SAD), and major depressive disorder (MDD); the frequency of above average anxiety and depressive symptoms using the Multidimensional Anxiety Scale for Children (MASC) and the Children's Depression Inventory (CDI); and the association between diagnoses and symptom severity.
resultsOne hundred twenty six children were included (mean age 10.7 years). The most common comorbid disorder was ADHD (37%), followed by GAD (21%), OCD (10%), MDD (2%) and SAD (2%). On the MASC, the separation anxiety/panic subscale score was higher than all other subscale scores (p<0.0001). Clinically significant anxiety symptoms were present in 20% of the sample based on the MASC Anxiety Disorders Index, while 6% were identified as potentially clinically depressed based on the CDI Total Score. Yale Global Tic Severity Scale scores were positively correlated with total scores on the MASC (r=0.22, p=0.03) and CDI (r=0.37, p=0.0002).
conclusionsRoutine screening children with TS for anxiety is warranted given the rate of comorbidity. Screening for depression in TS will have a higher yield in adolescents, adults, and children with more severe tics.
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Identifiers
29375629PMC5777687W2948213387What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.