Evidence map›Paper›PMID 29375581›Full record

ReviewFrontiers in immunology2017

The Interface between Fungal Biofilms and Innate Immunity.

John F Kernien, Brendan D Snarr, Donald C Sheppard, Jeniel E Nett

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 140 citations in OpenAlex.

  1. Beyond roughness: Lateral surface architecture drives Candida albicans virulence on denture polymers.Dental materials : official publication of the Academy of Dental Materials · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Immune interaction betweenFrontiers in cellular and infection microbiology · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Microbial Biofilms: Where Are We and Where Are We Going?The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025
    Article
  12. Fungal Biofilm: An Overview of the Latest Nano-Strategies.Antibiotics (Basel, Switzerland) · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Recent innovations and challenges in the treatment of fungal infections.Frontiers in cellular and infection microbiology · 2025
    Review
  19. International journal of molecular and cellular medicine · 2025
    Review
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

John F KernienDepartment of Medicine, University of Wisconsin, Madison, WI, United States.
Brendan D SnarrDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Donald C SheppardDepartment of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Jeniel E NettDepartment of Medicine, University of Wisconsin, Madison, WI, United States.
McGill University · CAUniversity of Wisconsin–Madison · US

Funding

Mechanisms of Candida Biofilm Immune EvasionK08AI108727 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NETT, JENIEL E · 2014 to 2018
$960k
Doris Duke Charitable Foundation 2017074NIAID NIH HHS K08 AI108727
6 · The paper itself

Abstract

Fungal biofilms are communities of adherent cells surrounded by an extracellular matrix. These biofilms are commonly found during infection caused by a variety of fungal pathogens. Clinically, biofilm infections can be extremely difficult to eradicate due to their resistance to antifungals and host defenses. Biofilm formation can protect fungal pathogens from many aspects of the innate immune system, including killing by neutrophils and monocytes. Altered immune recognition during this phase of growth is also evident by changes in the cytokine profiles of monocytes and macrophages exposed to biofilm. In this manuscript, we review the host response to fungal biofilms, focusing on how these structures are recognized by the innate immune system. Biofilms formed by

Indexed as

AspergillusbiofilmCandidafungiinnate immunitymatrixneutrophilneutrophil extracellular trap

Identifiers

PMID29375581
PMCPMC5767580
OpenAlexW2783354523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.