ArticleFrontiers in immunology2017
Detection of Pathogen Exposure in African Buffalo Using Non-Specific Markers of Inflammation.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 48 citations in OpenAlex.
- Non-specific markers of inflammation in bare-nosed wombats (Frontiers in veterinary science · 2024Article
- Epidemiology ofInternational journal for parasitology. Parasites and wildlife · 2023Article
- Strategies for managing marine disease.Ecological applications : a publication of the Ecological Society of America · 2022Article
- Viral dynamics and immune responses to foot-and-mouth disease virus in African buffalo (Syncerus caffer).Veterinary research · 2022Article
- Acute-phase protein concentrations in serum of clinically healthy and diseased European bison (Bison bonasus) - preliminary study.BMC veterinary research · 2022Article
- Diet and gut microbiome enterotype are associated at the population level in African buffalo.Nature communications · 2021Article
- Age of first infection across a range of parasite taxa in a wild mammalian population.Biology letters · 2020Article
- Erythrocyte sedimentation rate and hemoglobin-binding protein in free-living box turtles (Terrapene spp.).PloS one · 2020Article
- Elucidating cryptic dynamics ofEcology and evolution · 2020Article
- Bovine tuberculosis disturbs parasite functional trait composition in African buffalo.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detecting exposure to new or emerging pathogens is a critical challenge to protecting human, domestic animal, and wildlife health. Yet, current techniques to detect infections typically target known pathogens of humans or economically important animals. In the face of the current surge in infectious disease emergence, non-specific disease surveillance tools are urgently needed. Tracking common host immune responses indicative of recent infection may have potential as a non-specific diagnostic approach for disease surveillance. The challenge to immunologists is to identify the most promising markers, which ideally should be highly conserved across pathogens and host species, become upregulated rapidly and consistently in response to pathogen invasion, and remain elevated beyond clearance of infection. This study combined an infection experiment and a longitudinal observational study to evaluate the utility of non-specific markers of inflammation [NSMI; two acute phase proteins (haptoglobin and serum amyloid A), two pro-inflammatory cytokines (IFNγ and TNF-α)] as indicators of pathogen exposure in a wild mammalian species, African buffalo (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.