ReviewFrontiers in cellular neuroscience2017
Intrinsic and Extrinsic Neuromodulation of Olfactory Processing.
Review in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system.Journal of neurophysiology · 2026Article
- Foxg1 regulates the development of microvillous cells in the olfactory epithelium.Developmental biology · 2026Article
- Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system.Nature communications · 2025Article
- Three-factor learning in spiking neural networks: An overview of methods and trends from a machine learning perspective.Patterns (New York, N.Y.) · 2025Review
- Prominent involvement of acetylcholine dynamics in stable olfactory representation across the Drosophila brain.Nature communications · 2025Article
- The legacies of A. O. Dennis Willows and Peter A. Getting: neuroscience research usingJournal of neurophysiology · 2025Review
- Serotonergic amplification of odor-evoked neural responses maps onto flexible behavioral outcomes.eLife · 2024Article
- Augmenting insect olfaction performance through nano-neuromodulation.Nature nanotechnology · 2024Article
- Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila.Nature communications · 2023Article
- Neuromodulation and differential learning across mosquito species.Proceedings. Biological sciences · 2023Article
- Anatomic and neurochemical analysis of the palpal olfactory system in the red flour beetleFrontiers in cellular neuroscience · 2023Article
- Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions.Open biology · 2022Review
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Cortical feedback and gating in odor discrimination and generalization.PLoS computational biology · 2021Article
- Dopaminergic and serotonergic changes in rabbit fetal brain upon repeated gestational exposure to diesel engine exhaust.Archives of toxicology · 2021Article
- Modulation of Neural Microcircuits That Control Complex Dynamics in Olfactory Networks.Frontiers in cellular neuroscience · 2021Article
- Editorial: Bottom-Up and Top-Down: Molecules and Circuits That Underlie Chemosensory Behaviors.Frontiers in cellular neuroscience · 2021Article
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
- The Wiring Logic of an Identified Serotonergic Neuron That Spans Sensory Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Plasticity of Sniffing Pattern and Neural Activity in the Olfactory Bulb of Behaving Mice During Odor Sampling, Anticipation, and Reward.Neuroscience bulletin · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neuromodulation is a ubiquitous feature of neural systems, allowing flexible, context specific control over network dynamics. Neuromodulation was first described in invertebrate motor systems and early work established a basic dichotomy for neuromodulation as having either an intrinsic origin (i.e., neurons that participate in network coding) or an extrinsic origin (i.e., neurons from independent networks). In this conceptual dichotomy, intrinsic sources of neuromodulation provide a "memory" by adjusting network dynamics based upon previous and ongoing activation of the network itself, while extrinsic neuromodulators provide the context of ongoing activity of other neural networks. Although this dichotomy has been thoroughly considered in motor systems, it has received far less attention in sensory systems. In this review, we discuss intrinsic and extrinsic modulation in the context of olfactory processing in invertebrate and vertebrate model systems. We begin by discussing presynaptic modulation of olfactory sensory neurons by local interneurons (LNs) as a mechanism for gain control based on ongoing network activation. We then discuss the cell-class specific effects of serotonergic centrifugal neurons on olfactory processing. Finally, we briefly discuss the integration of intrinsic and extrinsic neuromodulation (metamodulation) as an effective mechanism for exerting global control over olfactory network dynamics. The heterogeneous nature of neuromodulation is a recurring theme throughout this review as the effects of both intrinsic and extrinsic modulation are generally non-uniform.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.