Evidence map›Paper›PMID 29375302›Full record

ArticleFrontiers in molecular neuroscience2017

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.

Svenja Kankowski, Benjamin Förstera, Aline Winkelmann, Pina Knauff, Erich E Wanker, Xintian A You, Marcus Semtner, Florian Hetsch, Jochen C Meier

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Extracellular KNature communications · 2026
    Article
  3. Article
  4. Two codes of RNA editing by deamination in human diseases.Experimental & molecular medicine · 2026
    Review
  5. HAMMER: Hairpin-based APOBEC3A-mediated mRNA editing reporter.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Cesium activates the neurotransmitter receptor for glycine.Frontiers in molecular neuroscience · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Svenja KankowskiDivision Cell Physiology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Benjamin FörsteraInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich, Munich, Germany.
Aline WinkelmannNeuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Pina KnauffInstitute of Cell Biology and Neurobiology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Erich E WankerNeuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Xintian A YouBioinformatics in Medicine, Zuse Institute Berlin, Berlin, Germany.
Marcus SemtnerCellular Neurosciences, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Florian HetschDivision Cell Physiology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Jochen C MeierDivision Cell Physiology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Max Delbrück Center · DETechnische Universität Braunschweig · DECharité - Universitätsmedizin Berlin · DELudwig-Maximilians-Universität München · DEZuse Institute Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease. It is therefore necessary to develop tools that allow identification of neuron types that express RNA-edited GlyR protein. In this study, we identify NH

Indexed as

epilepsyglycine receptorshippocampusligandsRNA editingtemporal lobe

Identifiers

PMID29375302
PMCPMC5768626
OpenAlexW2782804215

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.