ArticleApplied bionics and biomechanics2017
Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test.
Article in Applied bionics and biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Influence of the Cortical Layer Thickness and Trabecular Layer Pattern Density on 3D-Printed Femur Strength.Materials (Basel, Switzerland) · 2025Article
- Intermittent parathyroid hormone treatment affects the bone structural parameters and mechanical strength of the femoral neck after ovariectomy-induced osteoporosis in rats.Biomedical engineering online · 2022Article
- Different storage times and their effect on the bending load to failure testing of murine bone tissue.Scientific reports · 2020Article
- Rotary-jet spun polycaprolactone/nano-hydroxyapatite scaffolds modified by simulated body fluid influenced the flexural mode of the neoformed bone.Journal of materials science. Materials in medicine · 2020Article
- Protective effect of Glycyrrhiza glabra roots extract on bone mineral density of ovariectomized rats.BioMedicine · 2019Article
- Effect of two (short-term) storage methods on load to failure testing of murine bone tissue.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A biomechanical test is a good evaluation method that describes the structural, functional, and pathological differences in the bones, such as osteoporosis and fracture. The tensile test, compression test, and bending test are generally performed to evaluate the elastic modulus of the bone using mice. In particular, the femoral head compression test is mainly used for verifying the osteoporosis change of the femoral neck. This study conducted bone mineral density analysis using in vivo microcomputed tomography (micro-CT) to observe changes in osteoporosis over time. It proposed a method of identifying the elastic modulus of the femur in the normal group (CON group) and the osteoporotic group (OVX group) through finite element analysis based on the femoral head compression test and also conducted a comparative analysis of the results. Through the femoral head compression test, it was verified that the CON group's ultimate and yield loads were significantly higher than those of the OVX group. It was considered that this result was caused by the fact that the bone mineral density change by osteoporosis occurred in the proximal end more often than in the femur diaphysis. However, the elastic modulus derived from the finite element analysis showed no significant difference between the two groups.
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Registered trials
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