Evidence map›Paper›PMID 29375220›Full record

ArticleActa Cardiologica Sinica2018

Relationship between Fragmented QRS and NT-proBNP in Patients with ST Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention.

Qi Zhao, Ruoxi Zhang, Jingbo Hou, Bo Yu

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Article in Acta Cardiologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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  14. The relationship between galectin-3 levels and fragmented QRS (fQRS) in patients with heart failure with reduced left ventricular ejection fraction.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019
    Article
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  17. Fragmented QRS - Its significance.Indian pacing and electrophysiology journal
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Qi ZhaoDepartment of Cardiology, The 1st Affiliated Hospital of Harbin Medical University.
Ruoxi ZhangDepartment of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
Jingbo HouDepartment of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
Bo YuDepartment of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the relationship between the presence of fragmented QRS (fQRS) on electrocardiogram (ECG) and plasma NT-proBNP levels in patients with ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). The in-hospital prognostic value of the presence of fQRS was also assessed.

methodsIn this retrospective study, 216 patients with STEMI who were undergoing primary PCI were included. fQRS was identified in ECG following primary PCI. The fQRS included various morphologies of the QRS (< 120 ms), which included an additional R wave (R') or notching in the nadir of the S wave, or > 1R' (fragmentation) in 2 contiguous leads, corresponding to a major coronary artery territory. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were measured immediately, 24 and 48 hours after admition and the peak level was adopted. Patients were divided into two groups based on the presence (n = 126) or absence (n = 90) of a fQRS on ECG.

resultsNT-proBNP level was found to be significantly higher in fQRS (+) group compared to the fQRS (-) group (p < 0.001). The in-hospital advanced heart failure were found to be significantly more frequent in the fQRS (+) group. In logistic regression analysis, the fQRS ≥ 3 leads, fQRS in anterior leads, and NT-proBNP were independently related with in-hospital major adverse cardiac events that includes cardiovascular mortality, reinfarction, advanced heart failure, repeat target vessel revascularization, ventricular arrhythmias, atrioventricular block or sroke in the hospital. The area under the curve using the NTpro-BNP level for the prediction of fQRS was 0.809.

conclusionsThe presence of fQRS is significantly associated with NT-proBNP and left ventricular ejection fraction, which can predict left ventricular function in patients with STEMI. fQRS is a prognostic marker of impaired regional ventricular systolic function.

Indexed as

Fragmented QRS complexMyocardial infarctionN-terminal pro-brain natriuretic peptidePercutaneous coronary intervention

Identifiers

PMID29375220
PMCPMC5777939
OpenAlexW3024354313

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.