Evidence map›Paper›PMID 29375211›Full record

ArticleWorld journal of gastroenterology2018

Timing of surgery after neoadjuvant chemotherapy for gastric cancer: Impact on outcomes.

Yi Liu, Ke-Cheng Zhang, Xiao-Hui Huang, Hong-Qing Xi, Yun-He Gao, Wen-Quan Liang, Xin-Xin Wang, Lin Chen

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  4. Gastrointestinal Malignancies and the COVID-19 Pandemic: Evidence-Based Triage to Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Pooled it
  5. Trial
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  16. Current status and future perspectives on neoadjuvant therapy in gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Surgical Strategies in the Era of SARS-CoV-2.The Pan African medical journal · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yi LiuDepartment of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Ke-Cheng ZhangDepartment of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Xiao-Hui HuangDepartment of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Hong-Qing XiDepartment of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Yun-He GaoDepartment of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Wen-Quan LiangDepartment of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Xin-Xin WangDepartment of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Lin ChenDepartment of General Surgery & Institute of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China. chenlinbj301@163.com.
Creative Research Enterprises (United States) · USChinese People's Liberation Army · CNPeople's Liberation Army No. 150 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate whether the neoadjuvant chemotherapy (NACT)-surgery interval time significantly impacts the pathological complete response (pCR) rate and long-term survival.

methodsOne hundred and seventy-six patients with gastric cancer undergoing NACT and a planned gastrectomy at the Chinese PLA General Hospital were selected from January 2011 to January 2017. Univariate and multivariable analyses were used to investigate the impact of NACT-surgery interval time (< 4 wk, 4-6 wk, and > 6 wk) on pCR rate and overall survival (OS).

resultsThe NACT-surgery interval time and clinician T stage were independent predictors of pCR. The interval time > 6 wk was associated with a 74% higher odds of pCR as compared with an interval time of 4-6 wk (

conclusionThe NACT-surgery interval time is associated with pCR but has no impact on survival, and an interval time > 6 wk has a relatively high odds of pCR.

Indexed as

GastrectomyNeoadjuvant TherapyTime-to-TreatmentAdultAgedAntineoplastic AgentsChemotherapy, AdjuvantChinaChi-Square DistributionDisease-Free SurvivalDisease ProgressionFemaleHospitals, GeneralHumansKaplan-Meier EstimateLogistic ModelsAntineoplastic AgentsGastric cancerNeoadjuvant chemotherapyTiming of surgery

Identifiers

PMID29375211
PMCPMC5768944
OpenAlexW2783436034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.