Evidence map›Paper›PMID 29375198›Full record

Trial reportMediators of inflammation2017

A Prospective, Double-Blind, Randomized, Controlled Clinical Trial in the Gingivitis Prevention with an Oligomeric Proanthocyanidin Nutritional Supplement.

R M Díaz Sánchez, G Castillo-Dalí, A Fernández-Olavarría, R Mosquera-Pérez, J M Delgado-Muñoz, J L Gutiérrez-Pérez, D Torres-Lagares

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

R M Díaz SánchezOral Surgery Department, Dental School, University of Seville, Seville, Spain.ORCID 0000-0002-8475-4381
G Castillo-DalíOral Surgery Department, Dental School, University of Seville, Seville, Spain.
A Fernández-OlavarríaOral Surgery Department, Dental School, University of Seville, Seville, Spain.
R Mosquera-PérezOral Surgery Department, Dental School, University of Seville, Seville, Spain.
J M Delgado-MuñozOral Surgery Department, Dental School, University of Seville, Seville, Spain.
J L Gutiérrez-PérezOral Surgery Department, Dental School, University of Seville, Seville, Spain.
D Torres-LagaresOral Surgery Department, Dental School, University of Seville, Seville, Spain.ORCID 0000-0001-9302-7138
Universidad de Sevilla · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the effectiveness on tissue response of the new nutritional supplement made of oligomeric proanthocyanidins in induced gingivitis after 21 days of use. MATERIAL AND

methodsA prospective, double-blind, randomized, controlled clinical trial was carried out on 20 patients; it is divided into an experimental group and a control group after fulfilling the selection criteria. Patients had to come 4 times during the study to register the Silness and Löe index, the gingival bleeding index, the plaque index, the inflammatory crevicular fluid study (IL6), and the changes in the brightness of the gingiva. No complementary hygiene methods were allowed during the 21 days.

resultsThe Silness and Löe index was higher in the control group than in the experimental group, reaching a twofold difference between the groups (

conclusionOligomeric proanthocyanidins have an effect on the periodontal tissue's health. No effects on the accumulation of plaque on the tooth surface were found, so further studies are needed to determine the nature of the plaque.

Indexed as

AdultDental PlaqueDietary SupplementsDouble-Blind MethodFemaleGingivitisHumansInterleukin-6MaleProanthocyanidinsProspective StudiesIL6 protein, humanInterleukin-6Proanthocyanidins

Identifiers

PMID29375198
PMCPMC5742508
OpenAlexW2774092385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.