Evidence map›Paper›PMID 29375127›Full record

ArticleCellular & molecular immunology2018

Proteomic analysis reveals distinctive protein profiles involved in CD8

Weici Zhang, Ren Zhang, Jun Zhang, Ying Sun, Patrick Sc Leung, Guo-Xiang Yang, Zongwen Shuai, William M Ridgway, M Eric Gershwin

Abstract read
In one paragraph

Article in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Dietary therapy of murine primary biliary cholangitis induces hepatocellular steatosis: A cautionary tale.Liver international : official journal of the International Association for the Study of the Liver · 2024
    Article
  4. Targeting pathogenic CD8Nature communications · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Weici ZhangDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA, California. ddzhang@ucdavis.edu.
Ren ZhangDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA, California.
Jun ZhangDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA, California.
Ying SunDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA, California.
Patrick Sc LeungDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA, California.
Guo-Xiang YangDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA, California.
Zongwen ShuaiDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA, California.
William M RidgwayDivision of Immunology, Allergy and Rheumatology, University of Cincinnati, Cincinnati, 45267, OH, USA.
M Eric GershwinDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA, California. megershwin@ucdavis.edu.
University of California, Davis · US302 Military Hospital of China · CNAnhui Medical University · CNUniversity of Cincinnati · US

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
dnTGF Beta RII Mice and PBCR01DK090019 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERSHWIN, MERRILL E, RIDGWAY, WILLIAM M · 2010 to 2017
$3.8M
NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK090019
6 · The paper itself

Abstract

Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver, and T cells are critical drivers in this process. However, little is known about the regulation of their functional behavior during disease development. We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type II (dnTGFβRII) spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis (PBC). Adoptive transfer of CD8

Indexed as

Adoptive TransferAnalysis of VarianceAnimalsAutoimmune DiseasesBlood ProteinsCD8-Positive T-LymphocytesCholangitisDisease Models, AnimalFemaleLiverMiceMice, Inbred C57BLNatural Killer T-CellsProteomicsReceptor, Transforming Growth Factor-beta Type IISpleenBlood ProteinsReceptor, Transforming Growth Factor-beta Type IIautoimmune cholangitisCD8dnTGFβRII miceproteomic analysis

Identifiers

PMID29375127
PMCPMC6141482
OpenAlexW2791044721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.