ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2018
Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Is Preemptive Kidney Transplantation Associated With Improved Outcomes when Compared to Non-preemptive Kidney Transplantation in Children? A Systematic Review and Meta-Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2022Pooled it
- Effect of muscle stretching and isometric exercises on quality of life in children undergoing regular hemodialysis.Pediatric nephrology (Berlin, Germany) · 2024Trial
- Patient-reported measures in children and adolescents with chronic kidney disease and their validation: A scoping review.Pediatric nephrology (Berlin, Germany) · 2026Article
- The Palliation of Pediatric Kidney Transplantation.Pediatric transplantation · 2026Review
- Aligning Words With What Matters: Evaluation of a Nationwide Sample of Pediatric Kidney Transplant Educational Materials.Pediatric transplantation · 2026Article
- "Life renewed, obstacles persist": a systematic review of qualitative studies on the experiences of children and adolescents post-kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2026Review
- Social Representations of Bedside Milk Expression Among Mothers of Preterm Newborns in Neonatal Intensive Care Units.Journal of advanced nursing · 2026Article
- Mental health and kidney disease.Nature reviews. Nephrology · 2026Review
- The Lived Experiences of Children Who Have Undergone Kidney Replacement Therapy and Their Families: Protocol for a Qualitative Systematic Review.JMIR research protocols · 2026Article
- Resting-state EEG reveals slowing and altered functional connectivity in children and young adults with severe chronic kidney disease.Clinical neurophysiology practice · 2026Article
- Midterm Outcome of AB0 Incompatible Kidney Transplantation in Children and Adolescents-A Single Center Experience.Pediatric transplantation · 2026Article
- Listening to the multidisciplinary care team: exploring the pediatric palliative care needs in advanced chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2025Article
- Impact of parenteral nutrition on quality of life, the family and gastrointestinal symptoms in children with intestinal failure.Journal of pediatric gastroenterology and nutrition · 2025Article
- Quality of life in children at different stages of chronic kidney disease in a developing country.Pediatric nephrology (Berlin, Germany) · 2025Article
- Holistic care and symptom management for pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Socioeconomic Position and Health Among Children and Adolescents With CKD Across the Life-Course.Kidney international reports · 2024Review
- Patient-reported outcome measures in children, adolescents, and young adults with palliative care needs-a scoping review.BMC palliative care · 2023Article
- Health-related quality of life amongst children with chronic kidney disease in Malaysia: performance of the Bahasa Melayu version of the PedsQL 3.0 ESRD Module : (PedsQL 3.0 VerBATIM: version in Bahasa Melayu. Translated for use in Malaysia).Pediatric nephrology (Berlin, Germany) · 2023Article
- Do We Need Palliative Care in Pediatric Nephrology? Patients' and Caregivers' Disease Experience.Children (Basel, Switzerland) · 2023Article
- Editorial: Infections and posttransplant lymphoproliferative disease after pediatric kidney transplantation.Frontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other chronic health conditions, and to explore related patient factors. STUDY
designAll prevalent end-stage renal disease (ESRD) patients aged 8-18 years who spent at least 6 months on their current treatment modality in the Netherlands, Belgium, and part of Germany were approached to complete the Pediatric Quality of Life Inventory 4.0 (PedsQL™) questionnaire. We determined the differences between groups on PedsQL™ mean scores, the proportion of children with an impaired HRQoL (≥ 1 SD lower than the healthy norm), the proportion of problems on individual items of the PedsQL™, and the effect of time on current treatment. Linear regression models were used to explore determinants of HRQoL.
results192 out of 278 patients (20% preemptive transplant, 58% non-preemptive transplant, 22% dialysis) filled in the PedsQL™ (response rate 69%). Independent of treatment modality, patients had significantly lower mean scores and consequently higher proportions of impaired HRQoL on almost all domains compared to the healthy norm and other chronic health conditions. Patients with a preemptive transplant only reported higher scores on physical health compared to the other treatment modalities. Having comorbidities was the most important determinant associated with lower HRQoL scores.
conclusionDialysis and renal transplantation both have a severe impact on the HRQoL of children with ESRD. Physicians should be aware of this continuous burden. Furthermore, to develop tailored interventions for children with ESRD, qualitative studies are needed to gain more insight in the determinants of HRQoL in the different treatment modalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.