Evidence map›Paper›PMID 29374801›Full record

ReviewCurrent atherosclerosis reports2018

Premature Coronary Heart Disease in South Asians: Burden and Determinants.

Sarah T Ahmed, Hasan Rehman, Julia M Akeroyd, Mahboob Alam, Tina Shah, Ankur Kalra, Salim S Virani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sarah T AhmedHealth Policy, Quality & Informatics Program, Michael E. DeBakey Veterans Affairs Medical Center Health Services Research and Development Center for Innovations, 2002 Holcombe Blvd, Houston, TX, 77030, USA.
Hasan RehmanDepartment of Medicine, Houston Methodist Hospital, Houston, TX, USA.
Julia M AkeroydHealth Policy, Quality & Informatics Program, Michael E. DeBakey Veterans Affairs Medical Center Health Services Research and Development Center for Innovations, 2002 Holcombe Blvd, Houston, TX, 77030, USA.
Mahboob AlamSection of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Tina ShahSection of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Ankur KalraHarrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Salim S ViraniHealth Policy, Quality & Informatics Program, Michael E. DeBakey Veterans Affairs Medical Center Health Services Research and Development Center for Innovations, 2002 Holcombe Blvd, Houston, TX, 77030, USA. virani@bcm.edu.
Baylor College of Medicine · USHealth Services Research & Development · USMethodist Hospital · USUniversity Hospitals of Cleveland · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewWhile the burden of cardiovascular disease (CVD) is on the decline globally, it is on the rise among South Asians. South Asians are also believed to present early with coronary artery disease (CAD) compared with other ethnicities. RECENT

findingsSouth Asians have demonstrated a higher burden of premature CAD (PCAD) compared with other ethnicities. These findings are not limited to non-immigrant South Asians but have also been found in immigrant South Asians settled around the world. In this article, we first discuss studies evaluating PCAD among South Asians residing in South Asia and among South Asian immigrants in other countries. We then discuss several traditional risk factors that could explain PCAD in South Asians (diabetes, hypertension, dietary factors, obesity) and lipoprotein-associated risk (low HDL-C levels, higher triglycerides, and elevated apolipoprotein B levels). We then discuss several emerging areas of research among South Asians including the role of dysfunctional HDL, elevated lipoprotein(a), genetics, and epigenetics. Although various risk markers and risk factors of CAD have been identified in South Asians, how they impact therapy is not well-known. PCAD is prevalent in the South Asian population. Large-scale studies are needed to identify how this information can be rationally utilized for early identification of risk among South Asians, and how currently available therapies can mitigate this increased risk.

Indexed as

Age of OnsetAsiaCardiovascular DiseasesCost of IllnessHumansNeeds AssessmentPrevalenceRisk FactorsIndiaPakistanPremature CADPremature CHDSouth Asia

Identifiers

PMID29374801
OpenAlexW2788402127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.