Evidence map›Paper›PMID 29374629›Full record

SynthesisAnnals of the rheumatic diseases2018

Cross-phenotype analysis of Immunochip data identifies

Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth G C Smith, Miguel A González-Gay and 2 more

Erratum issuedOpen access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Annals of the rheumatic diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. [Research advances in the etiology and pathogenesis of immunoglobulin A vasculitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Review
  4. Article
  5. Article
  6. IgA Vasculitis: Influence ofJournal of clinical medicine · 2022
    Article
  7. Age as a risk factor in vasculitis.Seminars in immunopathology · 2022
    Review
  8. Article
  9. Review
  10. Review
  11. IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes.International journal of molecular sciences · 2021
    Review
  12. Review
  13. A new era for giant cell arteritis.Eye (London, England) · 2020
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Lourdes Ortiz-FernándezInstituto de Parasitologia y Biomedicina Lopez-Neyra, Granada, Spain.
Francisco David CarmonaDepartamento de Genética e Instituto de Biotecnología, Universidad de Granada, Granada, Spain.
Raquel López-MejíasEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
Maria Francisca González-EscribanoDepartment of Immunology, Hospital Universitario Virgen del Rocío (IBiS,CSIC, US), Sevilla, Spain.
Paul A LyonsDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
Ann W MorganLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Amr H SawalhaDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Peter A Merkel
Kenneth G C SmithDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
Miguel A González-GayEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
Javier MartínInstituto de Parasitologia y Biomedicina Lopez-Neyra, Granada, Spain.
Spanish GCA Study Group, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group
Instituto de Parasitología y Biomedicina "López - Neyra" · ESUniversity of Cambridge · GBHospital Universitario Virgen del Rocío · ESInstituto de Investigación Marqués de Valdecilla · ESUniversidad de Cantabria · ESUniversidad de Granada · ESUniversity of Leeds · GBUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · US

Funding

Characterizing the Takayasu Arteritis Genetic Risk in RPS9/LILRB3R01AR070148 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAWALHA, AMR H · 2017 to 2022
$1.7M
Department of Health NIHR-CS-012-016Medical Research Council MR/L019027/1Medical Research Council MR/N011775/1NIAMS NIH HHS R01 AR070148Wellcome Trust
6 · The paper itself

Abstract

objetiveSystemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we performed the first cross-phenotype meta-analysis of genetic data from different clinically distinct patterns of vasculitis.

methodsImmunochip genotyping data from 2465 patients diagnosed with giant cell arteritis, Takayasu's arteritis, antineutrophil cytoplasmic antibody-associated vasculitis or IgA vasculitis as well as 4632 unaffected controls were analysed to identify common susceptibility

resultsThe strongest association signal corresponded with an intergenic polymorphism located between

conclusionsThrough a combined analysis of Immunochip data, we have identified

Indexed as

PhenotypeAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisCase-Control StudiesEpigenesis, GeneticFemaleGenetic LociGenetic Predisposition to DiseaseGiant Cell ArteritisHLA-DQ AntigensHLA-DQ beta-ChainsHumansJumonji Domain-Containing Histone DemethylasesLinkage DisequilibriumMalePolymorphism, Single NucleotideProtein Array AnalysisHLA-DQA2 antigenHLA-DQ AntigensHLA-DQB1 antigenHLA-DQ beta-ChainsJumonji Domain-Containing Histone DemethylasesKDM4C protein, humanautoantibodiesoutcomes researchsystemic sclerosis

Identifiers

PMID29374629
PMCPMC5849568
OpenAlexW2784348437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.