ArticleJournal of biomedical optics2018
Shortwave-infrared Raman spectroscopic classification of water fractions in articular cartilage ex vivo.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- A multiphasic model for determination of mouse ascending thoracic aorta mass transport properties with and without aneurysm.Biomechanics and modeling in mechanobiology · 2025Article
- Preliminary Study for the Early Diagnosis of Osteoarthritis in Human Synovial Fluid Using ATR-FTIR Combined with Chemometrics.The archives of bone and joint surgery · 2025Article
- Holistic vibrational spectromics assessment of human cartilage for osteoarthritis diagnosis.Biomedical optics express · 2024Article
- Article
- Raman spectroscopy-based water measurements identify the origin of MRI T2 signal in human articular cartilage zones and predict histopathologic score.Journal of biophotonics · 2022Article
- Radial variation in biochemical composition of the bovine caudal intervertebral disc.JOR spine · 2019Article
- Environmentally-Controlled Near Infrared Spectroscopic Imaging of Bone Water.Scientific reports · 2019Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Water loss is an early onset indicator of osteoarthritis. Although Raman spectroscopy (RS) holds the potential for measurement of cartilage hydration, the knowledge of Raman OH-stretch bands of biological tissue is very limited. We assesed here the sensitivity of RS to identify and classify water types in the cartilage. Raman spectrum measurements over the high wavenumber range were employed to identify different water fractions in articular cartilage. Raman spectra were collected from wet and sequentially dehydrated cartilage along with pure collagen type II and chondroitin sulfate standards. OH-stretch band of cartilage is dominated by mobile water, up to 95% of total intensities. We identified six peaks in cartilage spectrum using second-derivative analysis: peaks at 3200 and 3650 cm-1 are associated with organic matrix (both collagen and proteglycan) and matrix-bound water molecules. Peaks at 3250, 3453, and 3630 cm-1 are associated with collagen and collagen-related water molecules, whereas the peak at 3520 cm-1 is associated with proteoglycan (PG) and PG-related water molecules. The current work is the first thorough analysis of the Raman OH-stretch band of the cartilage and with the knowledge generated by this study, it may now be possible to study on cartilage hydration by RS.
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Registered trials
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