Evidence map›Paper›PMID 29374372›Full record

ArticleCerebellum (London, England)2018

Targeting the CACNA1A IRES as a Treatment for Spinocerebellar Ataxia Type 6.

Parviz Daniel Hejazi Pastor, Xiaofei Du, Sarah Fazal, Andre N Davies, Christopher M Gomez

Open access · greenAbstract read
In one paragraph

Article in Cerebellum (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  6. Future targets for migraine treatment beyond CGRP.The journal of headache and pain · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Parviz Daniel Hejazi PastorDepartment of Neurology, University of Chicago, Chicago, IL, 60637, USA.
Xiaofei DuDepartment of Neurology, University of Chicago, Chicago, IL, 60637, USA.
Sarah FazalCellular Screening Center Core, University of Chicago, Chicago, IL, 60637, USA.
Andre N DaviesDepartment of Medicine, University of Chicago, Chicago, IL, 60637, USA.
Christopher M GomezDepartment of Neurology, University of Chicago, Chicago, IL, 60637, USA. cgomez@neurology.bsd.uchicago.edu.
University of Chicago · US

Funding

A novel role for a bicistronic calcium channel gene in neurodevelopment and neurodegenerationR01NS082788 · NINDS · UNIVERSITY OF CHICAGO · PI GOMEZ, CHRISTOPHER MANUEL · 2014 to 2019
$2.8M
Overlapping cistrons in a family of ion channel genesR01NS094665 · NINDS · UNIVERSITY OF CHICAGO · PI GOMEZ, CHRISTOPHER MANUEL · 2015 to 2019
$2.1M
Developing a novel microRNA-mediated therapeutic approach for SCA6R21NS094872 · NINDS · UNIVERSITY OF CHICAGO · PI GOMEZ, CHRISTOPHER MANUEL · 2017 to 2018
$446k
NINDS NIH HHS 1R01NS082788NINDS NIH HHS R01 NS082788NINDS NIH HHS R01 NS094665NINDS NIH HHS R01NS094665-01NINDS NIH HHS R21 NS094872
6 · The paper itself

Abstract

We have discovered that the P/Q-type voltage-gated Ca

Indexed as

AjmalineAnimalsCalcium ChannelsCalcium Channels, L-TypeCalcium Channels, N-TypeDisease Models, AnimalDose-Response Relationship, DrugGene Expression RegulationHEK293 CellsHumansInhibitory Concentration 50Internal Ribosome Entry SitesMicroRNAsMutationReceptors, Atrial Natriuretic FactorSpinocerebellar AtaxiasAjmalineatrial natriuretic factor receptor CCACNA1A protein, humanCalcium ChannelsCalcium Channels, L-TypeCalcium Channels, N-TypeInternal Ribosome Entry SitesL-type calcium channel alpha(1C)MicroRNAsReceptors, Atrial Natriuretic FactorVoltage-Gated Sodium Channel BlockersCapIndependentIRESmiRNASCA6Small moleculesSpinocerebellarTherapeutics

Identifiers

PMID29374372
PMCPMC5809202
OpenAlexW2793364480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.